Reactome | APBB1 [nucleoplasm]

APBB1 [nucleoplasm]

Stable Identifier

R-HSA-5683987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Amyloid beta A4 precursor protein-binding family B member 1, FE65, RIR

Locations in the PathwayBrowser for interactor UniProt:P08247 SYP

Expand all

External Reference Information

External Reference

UniProt:O00213 APBB1

Gene Names

APBB1, FE65, RIR

Chain

chain:1-710

Reference Genes

BioGPS Gene:322 APBB1

COSMIC (genes):APBB1 APBB1

CTD Gene:322 APBB1

dbSNP Gene:322 APBB1

ENSEMBL:ENSG00000166313 APBB1

ENSEMBL_homo_sapiens_GENE:ENSG00000166313.20 APBB1

HGNC:581 APBB1

KEGG Gene (Homo sapiens):322 APBB1

Monarch:322 APBB1

NCBI Gene:322 APBB1

OMIM:602709 APBB1

UCSC:O00213 APBB1

Reference Transcript

Other Identifiers

1101_at

11737977_x_at

11744278_a_at

11751142_x_at

11753908_x_at

11761470_x_at

202652_PM_at

202652_at

322

3360827

3360828

3360829

3360830

3360831

3360832

3360833

3360836

3360838

3360841

3360842

3360844

3360845

3360847

3360848

3360850

3360851

3360852

3360853

3360854

3360855

3360861

3360862

3360863

3360864

3360865

3360866

3360867

7946149

A_23_P1998

A_24_P372613

GE57800

GO:0000122

GO:0001540

GO:0003012

GO:0003682

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005886

GO:0006325

GO:0006351

GO:0006355

GO:0006915

GO:0006939

GO:0006974

GO:0007165

GO:0007409

GO:0010976

GO:0012501

GO:0016020

GO:0016607

GO:0023052

GO:0030027

GO:0030154

GO:0030426

GO:0031625

GO:0042393

GO:0042995

GO:0043065

GO:0043226

GO:0045202

GO:0045893

GO:0045944

GO:0048856

GO:0050714

GO:0050750

GO:0060090

GO:0070064

GO:0140110

GO:1902807

HMNXSV003004137

ILMN_1699646

ILMN_1769918

ILMN_1796271

L77864_at

PH_hs_0028275

g4502130_3p_at

g4502130_3p_x_at

Participates

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)

as an input of

APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)

Inferred To

APBB1 [nucleoplasm] (Bos taurus)

APBB1 [nucleoplasm] (Canis familiaris)

APBB1 [nucleoplasm] (Gallus gallus)

APBB1 [nucleoplasm] (Sus scrofa)

feh-1 [nucleoplasm] (Caenorhabditis elegans)

Apbb1 [nucleoplasm] (Mus musculus)

Apbb1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_016873130.1, NP_001244254.1, NP_001244250.1, NP_001155.1, NP_001244249.1, XP_011518342.1, NP_663722.1, NP_001244248.1, NP_001244255.1, NP_001244252.1

OpenTargets

ENSG00000166313

GeneCards

O00213

HPA

ENSG00000166313-APBB1

Ensembl

ENSP00000433338, ENSP00000477213, ENSP00000477069, ENST00000609331, ENST00000530885, ENSP00000476871, ENST00000608655, ENSP00000476442, ENSP00000476846, ENSP00000299402, ENST00000299402, ENST00000608645, ENST00000608394, ENST00000609360, ENSP00000311912, ENST00000608704, ENSP00000476646, ENSG00000166313, ENST00000311051

PRO

O00213

Pharos - Targets

O00213

PDB

2E45, 2HO2, 3D8F, 3D8D, 2IDH, 3D8E, 3DXC, 5NQH, 3DXD, 2OEI, 3DXE

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.912	10
UniProt:P05067-4 APP	2	APP (535-695) [cytosol] (R-HSA-9839084) APP [mitochondrial inner membrane] (R-HSA-9839060)	0.744	5
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.704	4
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.633	9
UniProt:Q02563 SV2A			0.556	3
UniProt:Q06481 APLP2	4	APLP2 [endoplasmic reticulum lumen] (R-HSA-8956784) p-APLP2 [endoplasmic reticulum lumen] (R-HSA-8956977) APLP2 [platelet alpha granule membrane] (R-HSA-8848898) APLP2 [plasma membrane] (R-HSA-8848902)	0.547	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.527	2
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.527	2

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