Reactome | APBB1 [nucleoplasm]

APBB1 [nucleoplasm]

Stable Identifier

R-HSA-5683987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Amyloid beta A4 precursor protein-binding family B member 1, FE65, RIR

Locations in the PathwayBrowser for interactor UniProt:Q06481 APLP2

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External Reference Information

External Reference

UniProt:O00213 APBB1

Gene Names

APBB1, FE65, RIR

Chain

chain:1-710

Reference Genes

COSMIC (genes):APBB1 APBB1

dbSNP Gene:322 APBB1

ENSEMBL:ENSG00000166313 APBB1

Participates

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Homo sapiens)

as an input of

APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)

Inferred To

APBB1 [nucleoplasm] (Bos taurus)

APBB1 [nucleoplasm] (Canis familiaris)

APBB1 [nucleoplasm] (Gallus gallus)

APBB1 [nucleoplasm] (Sus scrofa)

feh-1 [nucleoplasm] (Caenorhabditis elegans)

Apbb1 [nucleoplasm] (Mus musculus)

Apbb1 [nucleoplasm] (Rattus norvegicus)

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.912	10
UniProt:P05067-4 APP	2	APP (535-695) [cytosol] (R-HSA-9839084) APP [mitochondrial inner membrane] (R-HSA-9839060)	0.744	5
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.704	4
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.633	9
UniProt:Q02563 SV2A			0.556	3
UniProt:Q06481 APLP2	4	APLP2 [plasma membrane] (R-HSA-8848902) APLP2 [platelet alpha granule membrane] (R-HSA-8848898) p-APLP2 [endoplasmic reticulum lumen] (R-HSA-8956977) APLP2 [endoplasmic reticulum lumen] (R-HSA-8956784)	0.547	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.527	2
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.527	2

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