PIAS4 SUMOylates MDC1

Stable Identifier
R-HSA-5684052
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIAS4 SUMOylates MDC1 at lysine residue K1840. The exact timing and regulation of this modification is not known (Luo et al. 2012, Yin et al. 2012).
Literature References
PubMed ID Title Journal Year
22661230 SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

Seifert, A, Golebiowski, F, Maure, JF, Hay, RT, Chua, JS, Yin, Y

Genes Dev. 2012
22635276 Sumoylation of MDC1 is important for proper DNA damage response

Lou, Z, Yuan, J, Luo, K, Wang, L, Zhang, H

EMBO J. 2012
Participants
Participates
Catalyst Activity

SUMO transferase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm]

Orthologous Events
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