Reactome | MRN complex binds CDK2 and RBBP8

MRN complex binds CDK2 and RBBP8

Stable Identifier

R-HSA-5684081

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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In the S/G2 phase of the cell cycle, CDK2:CCNA (CDK2:cyclin A) complex and CtIP (RBBP8) are recruited to DNA double-strand breaks (DSBs) by the MRN complex. RBBP8 interacts with NBN (NBS1) and RAD50 subunits, while CDK2:CCNA interacts with the MRE11A subunit of the complex (Buis et al. 2012). RBBP8 functions as a homotetramer (Davies et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25558984	CtIP tetramer assembly is required for DNA-end resection and repair Davies, OR, Forment, JV, Sun, M, Belotserkovskaya, R, Coates, J, Galanty, Y, Demir, M, Morton, CR, Rzechorzek, NJ, Jackson, SP, Pellegrini, L	Nat. Struct. Mol. Biol.	2015
22231403	Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2 Buis, J, Stoneham, T, Spehalski, E, Ferguson, DO	Nat. Struct. Mol. Biol.	2012