Reactome | MRN complex binds CDK2 and RBBP8

MRN complex binds CDK2 and RBBP8

Stable Identifier

R-HSA-5684081

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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In the S/G2 phase of the cell cycle, CDK2:CCNA (CDK2:cyclin A) complex and CtIP (RBBP8) are recruited to DNA double-strand breaks (DSBs) by the MRN complex. RBBP8 interacts with NBN (NBS1) and RAD50 subunits, while CDK2:CCNA interacts with the MRE11A subunit of the complex (Buis et al. 2012). RBBP8 functions as a homotetramer (Davies et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25558984	CtIP tetramer assembly is required for DNA-end resection and repair Morton, CR, Forment, JV, Pellegrini, L, Jackson, SP, Coates, J, Galanty, Y, Belotserkovskaya, R, Demir, M, Sun, M, Davies, OR, Rzechorzek, NJ	Nat. Struct. Mol. Biol.	2015
22231403	Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2 Stoneham, T, Buis, J, Spehalski, E, Ferguson, DO	Nat. Struct. Mol. Biol.	2012