MRN complex binds CDK2 and RBBP8

Stable Identifier
R-HSA-5684081
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In the S/G2 phase of the cell cycle, CDK2:CCNA (CDK2:cyclin A) complex and CtIP (RBBP8) are recruited to DNA double-strand breaks (DSBs) by the MRN complex. RBBP8 interacts with NBN (NBS1) and RAD50 subunits, while CDK2:CCNA interacts with the MRE11A subunit of the complex (Buis et al. 2012). RBBP8 functions as a homotetramer (Davies et al. 2015).
Literature References
PubMed ID Title Journal Year
25558984 CtIP tetramer assembly is required for DNA-end resection and repair

Morton, CR, Forment, JV, Pellegrini, L, Jackson, SP, Coates, J, Galanty, Y, Belotserkovskaya, R, Demir, M, Sun, M, Davies, OR, Rzechorzek, NJ

Nat. Struct. Mol. Biol. 2015
22231403 Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Stoneham, T, Buis, J, Spehalski, E, Ferguson, DO

Nat. Struct. Mol. Biol. 2012
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