CDK2 phosphorylates RBBP8

Stable Identifier
R-HSA-5684096
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CDK2 phosphorylates RBBP8
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CDK2, in complex with cyclin A (CCNA), phosphorylates RBBP8 (CtIP) on serine residue S327 and threonine residue T847. Residue T847 is conserved in the yeast ortholog of CtIP, Sae2, and phosphorylation of T847 increases CtIP activity in DNA end resection. Serine S327 phosphorylation enables CtIP to bind BRCA1 (Buis et al. 2012).
Literature References
PubMed ID Title Journal Year
22231403 Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Stoneham, T, Buis, J, Spehalski, E, Ferguson, DO

Nat. Struct. Mol. Biol. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm]

Physical Entity
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CDK2 phosphorylates RBBP8 (Bos taurus)
CDK2 phosphorylates RBBP8 (Canis familiaris)
CDK2 phosphorylates RBBP8 (Drosophila melanogaster)
CDK2 phosphorylates RBBP8 (Gallus gallus)
CDK2 phosphorylates RBBP8 (Mus musculus)
CDK2 phosphorylates RBBP8 (Rattus norvegicus)
CDK2 phosphorylates RBBP8 (Schizosaccharomyces pombe)
CDK2 phosphorylates RBBP8 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-19)
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