ATM phosphorylates RBBP8

Stable Identifier
R-HSA-5684140
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ATM phosphorylates RBBP8
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CDK2-mediated phosphorylation of RBBP8 (CtIP) triggers ATM-mediated phosphorylation of RBBP8 on several ATM consensus SQ/TQ sites. The ATM phosphorylation site at threonine residue T859 of RBBP8 is evolutionarily conserved and seems to be particularly important for the RBBP8-promoted resection of DNA double-strand break (DSB) ends (Wang et al. 2013).
Literature References
PubMed ID Title Journal Year
23468639 The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair

Wang, H, Yates, JR, Chen, DJ, Shi, LZ, Han, X, Wong, CC, Wu, X, Zhu, Q, Berns, MW, Shao, Z, Truong, LN, Chen, L, Hwang, PY

PLoS Genet. 2013
Participants
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Output
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Catalyst Activity

protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]

Physical Entity
DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
ATM phosphorylates RBBP8 (Bos taurus)
ATM phosphorylates RBBP8 (Canis familiaris)
ATM phosphorylates RBBP8 (Drosophila melanogaster)
ATM phosphorylates RBBP8 (Gallus gallus)
ATM phosphorylates RBBP8 (Mus musculus)
ATM phosphorylates RBBP8 (Rattus norvegicus)
ATM phosphorylates RBBP8 (Schizosaccharomyces pombe)
ATM phosphorylates RBBP8 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-19)
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