CDK2-mediated phosphorylation of RBBP8 (CtIP) triggers ATM-mediated phosphorylation of RBBP8 on several ATM consensus SQ/TQ sites. The ATM phosphorylation site at threonine residue T859 of RBBP8 is evolutionarily conserved and seems to be particularly important for the RBBP8-promoted resection of DNA double-strand break (DSB) ends (Wang et al. 2013).
Wang, H, Yates, JR, Chen, DJ, Shi, LZ, Han, X, Wong, CC, Wu, X, Zhu, Q, Berns, MW, Shao, Z, Truong, LN, Chen, L, Hwang, PY
protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
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