3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105

Stable Identifier
Reaction [uncertain]
Homo sapiens
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IKBKB-induced proteolysis of NFkB p105 to p50 releases MAP3K8 (TPL2) from the complex with NFkB p105 and ABIN2. On TLR or IL1beta stimulation, dissociated MAP3K8 with an adequate phosphorylation state activates MAP2K (MKK1/2) and consequently MAPK1/3 (ERK1/2).

Literature References
PubMed ID Title Journal Year
12832462 NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

Belich, MP, Ley, SC, Gamblin, SJ, Beinke, S, Smerdon, SJ, Walker, PA, Lang, V, Deka, J, Howell, S

Mol Cell Biol 2003
12667451 NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

Waterfield, MR, Norman, LP, Zhang, M, Sun, SC

Mol Cell 2003
22988300 I?B kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400

Ley, SC, Mambole-Dema, A, Ben-Addi, A, Morrice, N, Roget, K, Abbott, DW, Janzen, J, Yang, HT, Gantke, T

Mol. Cell. Biol. 2012
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