IKBKB phosphorylates TPL2 (MAP3K8) at Ser400

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The activity of tumor progression locus-2 (TPL2, also known as COT and MAP3K8) is regulated by means of phosphorylation. MAP3K8 undergoes phosphorylated on S400 in its C-terminal tail to activate MAP2Ks (MEK1/2) following LPS stimulation of macrophages. Different experimental systems have suggested that S400 is either autophosphosphorylated by MAPK3P8 (IL-1?-stimulated IL-1R-293T cells) or transphosphorylated by an unknown kinase (LPS-stimulated RAW264.7 macrophages).

Literature References
PubMed ID Title Journal Year
19754427 IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Cohen, P, Baltzis, D, McManus, E, Peggie, M, Handoyo, H, Stafford, MJ

Biochem. J. 2009
22988300 I?B kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400

Ley, SC, Mambole-Dema, A, Ben-Addi, A, Morrice, N, Roget, K, Abbott, DW, Janzen, J, Yang, HT, Gantke, T

Mol. Cell. Biol. 2012
16806191 Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62

Cohen, P, Morrice, NA, Peggie, MW, Stafford, MJ

FEBS Lett. 2006
Catalyst Activity

IkappaB kinase activity of p-S177,S181-IKKB:IKKA:NEMO [cytosol]

Orthologous Events
Cite Us!