pro-SFTPC translocates from ER membrane to multivesicle body

Stable Identifier
R-HSA-5684868
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, multivesicular body lumen
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pro-SFTPC translocates from ER membrane to multivesicle body
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Surfactant proteins (SFTPs) are trafficked from the ER membrane to lamellar bodies (LBs) via the multi-vesicle body (MVB). The pro-SFTPs B and C are cleaved here to produce functional SFTPs (Conkright et al. 2001).

Literature References
PubMed ID Title Journal Year
11278984 Secretion of surfactant protein C, an integral membrane protein, requires the N-terminal propeptide

Weaver, TE, Trapnell, B, Voorhout, WF, Na, CL, Conkright, JJ, Glasser, SW, Bridges, JP

J. Biol. Chem. 2001
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Orthologous Events
pro-SFTPC translocates from ER membrane to multivesicle body (Bos taurus)
pro-SFTPC translocates from ER membrane to multivesicle body (Canis familiaris)
pro-SFTPC translocates from ER membrane to multivesicle body (Gallus gallus)
pro-SFTPC translocates from ER membrane to multivesicle body (Mus musculus)
pro-SFTPC translocates from ER membrane to multivesicle body (Rattus norvegicus)
pro-SFTPC translocates from ER membrane to multivesicle body (Sus scrofa)
pro-SFTPC translocates from ER membrane to multivesicle body (Xenopus tropicalis)
Authored
Jassal, B  (2015-03-23)
Reviewed
D'Eustachio, P  (2015-08-17)
Created
Jassal, B  (2015-03-23)
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