Reactome | p-T309-RAD51 [nucleoplasm]

p-T309-RAD51 [nucleoplasm]

Stable Identifier

R-HSA-5685231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser for interactor UniProt:Q6NVH7 SWAP1

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External Reference Information

External Reference

UniProt:Q06609 RAD51

Gene Names

RAD51, RAD51A, RECA

Chain

initiator methionine:, chain:2-339

Reference Genes

BioGPS Gene:5888 RAD51

COSMIC (genes):RAD51 RAD51

CTD Gene:5888 RAD51

dbSNP Gene:5888 RAD51

ENSEMBL:ENSG00000051180 RAD51

ENSEMBL_homo_sapiens_GENE:ENSG00000051180.17 RAD51

HGNC:9817 RAD51

KEGG Gene (Homo sapiens):5888 RAD51

Monarch:5888 RAD51

NCBI Gene:5888 RAD51

OMIM:179617 RAD51

UCSC:Q06609 RAD51

Reference Transcript

Other Identifiers

11734841_a_at

16799637

1872_at

205023_PM_at

205023_at

205024_PM_s_at

205024_s_at

3590087

3590089

3590090

3590091

3590092

3590093

3590094

3590095

3590096

3590097

3590098

3590099

3590100

5888

7982792

A_23_P88731

D14134_at

GE57077

GO:0000150

GO:0000152

GO:0000166

GO:0000228

GO:0000278

GO:0000722

GO:0000724

GO:0000730

GO:0000781

GO:0000785

GO:0000793

GO:0000794

GO:0000800

GO:0001673

GO:0001932

GO:0003677

GO:0003682

GO:0003690

GO:0003697

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006259

GO:0006260

GO:0006268

GO:0006281

GO:0006310

GO:0006312

GO:0006974

GO:0007131

GO:0008094

GO:0010569

GO:0010833

GO:0016605

GO:0016787

GO:0016887

GO:0017116

GO:0019899

GO:0022414

GO:0023052

GO:0031297

GO:0032200

GO:0032991

GO:0035861

GO:0036211

GO:0036297

GO:0042148

GO:0042802

GO:0043226

GO:0048471

GO:0051106

GO:0051321

GO:0065003

GO:0070182

GO:0070192

GO:0071312

GO:0071479

GO:0072711

GO:0072757

GO:0099182

GO:0140013

GO:0140097

GO:0140299

GO:0140657

GO:0140664

GO:1990414

GO:1990426

GO:1990918

GO:2000001

HMNXSV003027624

ILMN_1795609

ILMN_2257432

ILMN_2363027

PH_hs_0026109

TC15000292.hg

TC15002160.hg

g4506388_3p_a_at

Participates

as a component of

as an input of

as an output of

CHEK1 phosphorylates RAD51 (Homo sapiens)

Other forms of this molecule

RAD51 [nucleoplasm]

Inferred To

phospho-RAD51 [nucleoplasm] (Sus scrofa)

phospho-p-T309-RAD51 [nucleoplasm] (Bos taurus)

phospho-p-T309-RAD51 [nucleoplasm] (Canis familiaris)

phospho-p-T309-RAD51 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-T309-RAD51 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T309-RAD51 [nucleoplasm] (Gallus gallus)

phospho-p-T309-RAD51 [nucleoplasm] (Mus musculus)

phospho-p-T309-RAD51 [nucleoplasm] (Plasmodium falciparum)

phospho-p-T309-RAD51 [nucleoplasm] (Rattus norvegicus)

phospho-p-T309-RAD51 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-T309-RAD51 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-rad51 [nucleoplasm] (Danio rerio)

phospho-rad51 [nucleoplasm] (Xenopus tropicalis)

phospho-rad-51 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-threonine at 309

Coordinate

309

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_002866.2, XP_011520161.1, XP_011520159.1, NP_001157742.1, NP_597994.3, XP_006720689.1, NP_001157741.1, XP_011520162.1, XP_011520160.1, XP_011520163.1

OpenTargets

ENSG00000051180

GeneCards

Q06609

HPA

ENSG00000051180-RAD51

ZINC - Substances

RAD51_HUMAN

ZINC target

Q06609

Ensembl

ENST00000557850, ENSP00000267868, ENSG00000051180, ENSP00000433924, ENSP00000493712, ENSP00000406602, ENST00000532743, ENST00000382643, ENST00000423169, ENST00000645673, ENSP00000454176, ENST00000267868, ENSP00000372088

PRO

Q06609

Pharos - Targets

Q06609

Orphanet

15183

ZINC - Predictions - Purchasable

RAD51_HUMAN

PDB

5NP7, 8XBW, 5H1C, 5H1B, 8XBX, 7C9A, 8BQ2, 5JZC, 8JNF, 8XBU, 1B22, 8JNE, 8XBV, 8JND, 5NWL, 8XBT, 1N0W, 8BR2, 8PBC, 8PBD, 7EJC, 8BSC, 8GYK, 8XBY, 7EJE

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.982	46
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.916	11
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.845	9
UniProt:Q96B01-2 RAD51AP1			0.791	6
UniProt:Q96B01-3 RAD51AP1			0.75	6
UniProt:O43542 XRCC3	1	XRCC3 [nucleoplasm] (R-HSA-5685303)	0.729	5
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.718	6
UniProt:O43502 RAD51C	1	RAD51C [nucleoplasm] (R-HSA-217039)	0.662	6
UniProt:Q14159 SPIDR	1	SPIDR [nucleoplasm] (R-HSA-5686408)	0.659	6
UniProt:P43351 RAD52	3	monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm] (R-HSA-4568909) RAD52 [nucleoplasm] (R-HSA-62639) p-Y104-RAD52 [nucleoplasm] (R-HSA-5686588)	0.635	3
ChEBI:15422 ATP			0.623	11
UniProt:O75417-1 POLQ			0.602	3
UniProt:P28347 TEAD1	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.564	2
UniProt:P36601	2	RAD51 [nucleoplasm] (R-SPO-62637) phospho-p-T309-RAD51 [nucleoplasm] (R-SPO-5685231)	0.553	2
IntAct:EBI-2307559 DT40			0.544	3
IntAct:EBI-2307713 PHIX174			0.544	3
UniProt:Q96KN1 LRAT2			0.543	4
UniProt:P11245 NAT2	2	AcC-NAT2 [cytosol] (R-HSA-158833) NAT2 [cytosol] (R-HSA-158692)	0.543	4
UniProt:Q9BZ95 NSD3	1	WHSC1L1 [nucleoplasm] (R-HSA-1183230)	0.543	4
UniProt:Q86XE0 SNX32			0.527	2
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.527	2
UniProt:Q6NVH7 SWAP1			0.524	2
UniProt:O14757 CHEK1	3	CHEK1 [cytosol] (R-HSA-205285) CHEK1 [nucleoplasm] (R-HSA-113826) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.524	3
UniProt:Q14676 MDC1	6	monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) MDC1 [nucleoplasm] (R-HSA-75231)	0.524	3
UniProt:Q13007 IL24	1	IL24 [extracellular region] (R-HSA-448438)	0.508	2
UniProt:Q00341 HDLBP	1	HDLBP [plasma membrane] (R-HSA-8858026)	0.499	2
UniProt:Q86YA3 ZGRF1			0.471	2
UniProt:Q9BQ15 NABP2	1	NABP2 [nucleoplasm] (R-HSA-6814916)	0.463	2

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