CHEK1 phosphorylates BRCA2

Stable Identifier
R-HSA-5685242
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CHEK1 phosphorylates BRCA2
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CHEK1 phosphorylates BRCA2 on threonine residue T3887, in the C-terminal region of BRCA2. CHEK1-mediated BRCA2 phosphorylation, as well as CHEK1 mediated RAD51 phosphorylation, promotes the association of BRCA2 with RAD51 (Bahassi et al. 2008).
Literature References
PubMed ID Title Journal Year
18317453 The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

Ovesen, JL, Riesenberg, AL, Bahassi, EM, Stambrook, PJ, Hasty, PE, Bernstein, WZ

Oncogene 2008
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Catalyst Activity

protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]

Physical Entity
p-S317,S345-CHEK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-26)
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