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XRCC3 [nucleoplasm]
Stable Identifier
R-HSA-5685303
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA repair protein XRCC3, X-ray repair cross-complementing protein 3
Locations in the PathwayBrowser for interactor UniProt:Q6NVH7 SWAP1
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
CX3 complex formation (Homo sapiens)
XRCC3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43542 XRCC3
Gene Names
XRCC3
Chain
chain:1-346
Reference Genes
BioGPS Gene:7517 XRCC3
COSMIC (genes):XRCC3 XRCC3
CTD Gene:7517 XRCC3
dbSNP Gene:7517 XRCC3
ENSEMBL:ENSG00000126215 XRCC3
ENSEMBL_homo_sapiens_GENE:ENSG00000126215.14 XRCC3
HGNC:12830 XRCC3
KEGG Gene (Homo sapiens):7517 XRCC3
Monarch:7517 XRCC3
NCBI Gene:7517 XRCC3
OMIM:600675 XRCC3
Reference Transcript
RefSeq:NM_005432.3 XRCC3
RefSeq:NM_001100118.1 XRCC3
RefSeq:XM_005268046.2 XRCC3
RefSeq:NM_001100119.1 XRCC3
RefSeq:XM_011537138.2 XRCC3
Other Identifiers
11724839_a_at
16797025
216299_PM_s_at
216299_s_at
3580836
3580837
3580838
3580839
3580840
3580845
3580848
3580850
3580852
3580853
3580854
3580855
3580856
3580857
3580858
3580859
3580860
3580861
3580863
3580868
3580870
3580871
3580873
37094_at
7517
7981447
A_23_P48470
A_33_P3301524
GE54284
GO:0000166
GO:0000278
GO:0000400
GO:0000722
GO:0000724
GO:0000781
GO:0003677
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006259
GO:0006281
GO:0006310
GO:0006974
GO:0007010
GO:0007059
GO:0008821
GO:0010033
GO:0010824
GO:0016787
GO:0023052
GO:0032200
GO:0033065
GO:0036297
GO:0043226
GO:0045003
GO:0048471
GO:0071140
GO:0090267
GO:0090656
GO:0090657
GO:0090737
GO:0140014
GO:0140097
GO:0140299
GO:0140657
GO:0140664
HMNXSV003048514
Hs.99742.1.S1_3p_a_at
ILMN_1696266
PH_hs_0034355
TC14001542.hg
Participates
as an input of
CX3 complex formation (Homo sapiens)
as a component of
CX3 complex [nucleoplasm] (Homo sapiens)
Inferred To
Xrcc3 [nucleoplasm]
(Rattus norvegicus)
XRCC3 [nucleoplasm]
(Bos taurus)
XRCC3 [nucleoplasm]
(Canis familiaris)
XRCC3 [nucleoplasm]
(Gallus gallus)
XRCC3 [nucleoplasm]
(Mus musculus)
XRCC3 [nucleoplasm]
(Plasmodium falciparum)
XRCC3 [nucleoplasm]
(Sus scrofa)
xrcc3 [nucleoplasm]
(Danio rerio)
xrcc3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005268103.1
,
NP_005423.1
,
NP_001093588.1
,
NP_001093589.1
,
XP_011535440.1
OpenTargets
ENSG00000126215
HPA
ENSG00000126215-XRCC3
GeneCards
O43542
Ensembl
ENSP00000451362
,
ENSG00000126215
,
ENST00000554913
,
ENST00000553264
,
ENST00000555055
,
ENST00000352127
,
ENSP00000451974
,
ENSP00000343392
,
ENSP00000452598
PRO
O43542
Pharos - Targets
O43542
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43502 RAD51C
1
RAD51C [nucleoplasm]
(R-HSA-217039)
0.94
12
UniProt:Q06609 RAD51
2
RAD51 [nucleoplasm]
(R-HSA-62637)
p-T309-RAD51 [nucleoplasm]
(R-HSA-5685231)
0.729
5
UniProt:Q9NS69 TOMM22
1
TOMM22 [mitochondrial outer membrane]
(R-HSA-1252180)
0.643
3
UniProt:Q86YC2 PALB2
20
PALB2 Y28C [nucleoplasm]
(R-HSA-9724169)
PALB2 L35P [nucleoplasm]
(R-HSA-9724168)
PALB2 L24S [nucleoplasm]
(R-HSA-9724172)
PALB2 L21A [nucleoplasm]
(R-HSA-9704339)
PALB2 R37H [nucleoplasm]
(R-HSA-9724178)
PALB2 L21F [nucleoplasm]
(R-HSA-9704347)
PALB2 E12* [nucleoplasm]
(R-HSA-9704349)
PALB2 R37C [nucleoplasm]
(R-HSA-9724188)
PALB2 L35F [nucleoplasm]
(R-HSA-9704338)
PALB2 L947F [nucleoplasm]
(R-HSA-9724554)
PALB2 G1043D [nucleoplasm]
(R-HSA-9724584)
PALB2 T1030I [nucleoplasm]
(R-HSA-9704424)
PALB2 T841Qfs*10 [nucleoplasm]
(R-HSA-9704749)
PALB2 L1119P [nucleoplasm]
(R-HSA-9724589)
PALB2 L947S [nucleoplasm]
(R-HSA-9724557)
PALB2 L1143P [nucleoplasm]
(R-HSA-9704428)
PALB2 L1070P [nucleoplasm]
(R-HSA-9724556)
PALB2 C77Vfs*100 [nucleoplasm]
(R-HSA-9704738)
PALB2 L939W [nucleoplasm]
(R-HSA-9704417)
PALB2 L961P [nucleoplasm]
(R-HSA-9724583)
0.577
3
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:Q9P296 C5AR2
1
C5AR2 [plasma membrane]
(R-HSA-964798)
0.527
2
UniProt:Q03405 PLAUR
7
PLAUR [endoplasmic reticulum membrane]
(R-HSA-162703)
GPI-PLAUR [endoplasmic reticulum membrane]
(R-HSA-162687)
PLAUR(306-335) [endoplasmic reticulum lumen]
(R-HSA-162707)
PLAUR(23-335) [endoplasmic reticulum membrane]
(R-HSA-162866)
GPI-PLAUR [plasma membrane]
(R-HSA-158946)
PLAUR [plasma membrane]
(R-HSA-6806165)
GPI-PLAUR [specific granule membrane]
(R-HSA-6806143)
0.527
2
UniProt:O14498 ISLR
2
ISLR [extracellular region]
(R-HSA-8848919)
ISLR [platelet alpha granule lumen]
(R-HSA-8848912)
0.527
2
UniProt:P51587 BRCA2
20
BRCA2 D2983Ffs*34 [cytosol]
(R-HSA-9709538)
BRCA2 K2555* [cytosol]
(R-HSA-9711337)
BRCA2 N2553Tfs*95 [cytosol]
(R-HSA-9712872)
BRCA2 T2685Hfs*9 [cytosol]
(R-HSA-9712879)
BRCA2 K2674Rfs*2 [cytosol]
(R-HSA-9712610)
BRCA2 S3231* [cytosol]
(R-HSA-9711458)
BRCA2 I2675Dfs*6 [cytosol]
(R-HSA-9712869)
BRCA2 R2625* [cytosol]
(R-HSA-9711482)
BRCA2 E3071* [cytosol]
(R-HSA-9711354)
BRCA2 V2716Wfs*17 [cytosol]
(R-HSA-9712761)
BRCA2 W2586* [cytosol]
(R-HSA-9711487)
BRCA2 P2767Lfs*10 [cytosol]
(R-HSA-9712509)
BRCA2 K3032* [cytosol]
(R-HSA-9711485)
BRCA2 S2835* [cytosol]
(R-HSA-9711345)
BRCA2 Y3006* [cytosol]
(R-HSA-9711222)
BRCA2 L2926* [cytosol]
(R-HSA-9711348)
BRCA2 R3128* [cytosol]
(R-HSA-9711177)
BRCA2 E2599* [cytosol]
(R-HSA-9711304)
BRCA2 E2571* [cytosol]
(R-HSA-9711560)
BRCA2 Y2977* [cytosol]
(R-HSA-9711182)
0.527
2
UniProt:Q9UQV4 LAMP3
0.527
2
UniProt:Q6NVH7 SWAP1
0.524
2
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