Reactome | BCDX2 complex stabilizes RAD51 filament

BCDX2 complex stabilizes RAD51 filament

Stable Identifier

R-HSA-5685341

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        BCDX2 complex stabilizes RAD51 filament (Homo sapiens)

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The BCDX2 complex, composed of RAD51 paralogs RAD51B, RAD51C, RAD51D and XRCC2, preferentially binds at the ends of 3' overhanging ssDNA created by resection of DNA double-strand breaks (DSBs). The BCDX2 complex stabilizes nucleoprotein filaments formed by BRCA2-mediated RAD51 loading onto ssDNA (Masson et al. 2001, Chun et al. 2013). The BCDX2 complex may act by inhibiting displacement of RAD51 by BLM helicase (Amunugama et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23149936	Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway Buechelmaier, ES, Powell, SN, Chun, J	Mol. Cell. Biol.	2013
11751635	Identification and purification of two distinct complexes containing the five RAD51 paralogs Benson, FE, Shah, R, Masson, JY, West, SC, Stasiak, AZ, Tarsounas, MC, Stasiak, A, McIlwraith, MJ	Genes Dev.	2001
23810717	The HsRAD51B-HsRAD51C stabilizes the HsRAD51 nucleoprotein filament Fishel, R, Amunugama, R, Groden, J	DNA Repair (Amst.)	2013