Reactome | PPP6C [cytosol]

PPP6C [cytosol]

Stable Identifier

R-HSA-5685719

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        PP6 dephosphorylates SEC24 (Homo sapiens)
        
        PP6 [cytosol] (Homo sapiens)
        
        PPP6C [cytosol] (Homo sapiens)
        
        PPP6C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00743 PPP6C

Gene Names

PPP6C, PPP6

Chain

initiator methionine:1, chain:1-305, chain:2-305

Reference Genes

BioGPS Gene:5537 PPP6C

COSMIC (genes):PPP6C PPP6C

CTD Gene:5537 PPP6C

dbSNP Gene:5537 PPP6C

ENSEMBL:ENSG00000119414 PPP6C

HGNC:9323 PPP6C

KEGG Gene (Homo sapiens):5537 PPP6C

Monarch:5537 PPP6C

NCBI Gene:5537 PPP6C

OMIM:612725 PPP6C

UCSC:O00743 PPP6C

Reference Transcript

Other Identifiers

0003130433

11727048_s_at

11727049_s_at

11727050_a_at

11729600_a_at

11729601_a_at

11740707_a_at

11748125_a_at

17098395

203529_at

206174_s_at

225426_at

225429_at

3225344

3225349

3225350

3225351

3225352

3225353

3225354

3225359

3225360

3225361

3225362

3225366

3225368

3225375

3225376

37581_at

53149_at

5537

64005_at

8164155

A_23_P355385

A_23_P94623

A_24_P369154

A_24_P81298

GE58721

GO:0000082

GO:0000278

GO:0002376

GO:0003674

GO:0004721

GO:0004722

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006259

GO:0006464

GO:0006470

GO:0006810

GO:0006950

GO:0007004

GO:0007049

GO:0008150

GO:0009058

GO:0016192

GO:0016787

GO:0016791

GO:0022607

GO:0034641

GO:0042592

GO:0043167

GO:0043226

GO:0045087

GO:0046872

GO:0048208

GO:0051276

GO:0061024

GO:0065003

GO:0106306

GO:0106307

HMNXSV003028937

Hs.7256.1.A1_3p_at

Hs.7256.1.A2_3p_at

ILMN_1664921

PH_hs_0017306

PH_hs_0036088

TC09001588.hg

X92972_at

g5729987_3p_s_at

g7706488_3p_at

Participates

as a component of

PP6 [cytosol] (Homo sapiens)

Other forms of this molecule

PPP6C [nucleoplasm]

Inferred To

PPP6C [cytosol] (Bos taurus)

PPP6C [cytosol] (Canis familiaris)

PPP6C [cytosol] (Gallus gallus)

PPP6C [cytosol] (Sus scrofa)

Ppp6c [cytosol] (Mus musculus)

Ppp6c [cytosol] (Rattus norvegicus)

ppp6c [cytosol] (Danio rerio)

ppp6c [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001116841.1, NP_001116827.1, NP_002712.1

OpenTargets

ENSG00000119414

HPA

ENSG00000119414-PPP6C

GeneCards

O00743

Ensembl

ENSP00000362648, ENSP00000392147, ENST00000451402, ENSP00000411744, ENST00000373547, ENSG00000119414, ENST00000415905

PRO

O00743

Pharos - Targets

O00743

HMDB Protein

HMDBP08688

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	MAP3K7 [plasma membrane] (R-HSA-9012677) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) p-T187-MAP3K7 [cytosol] (R-HSA-206014) p-MAP3K7 [cytosol] (R-HSA-168163) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.602	4
UniProt:P78527 PRKDC	4	PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302)	0.527	2