Reactome | p-S738,T744 SEC23A [cytosol]

p-S738,T744 SEC23A [cytosol]

Stable Identifier

R-HSA-5685740

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein transport protein Sec23A, S23A_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        p-S738,T744 SEC23A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15436 SEC23A

Gene Names

SEC23A

Chain

initiator methionine:, chain:2-765

Reference Genes

BioGPS Gene:10484 SEC23A

COSMIC (genes):SEC23A SEC23A

CTD Gene:10484 SEC23A

dbSNP Gene:10484 SEC23A

ENSEMBL:ENSG00000100934 SEC23A

HGNC:10701 SEC23A

KEGG:hsa:10484 SEC23A

Monarch:10484 SEC23A

NCBI Gene:10484 SEC23A

OMIM:610511 SEC23A

UCSC:Q15436 SEC23A

Reference Transcript

RefSeq:NM_006364.3 SEC23A

Other Identifiers

10484

11722354_at

11747925_a_at

11749485_x_at

11752872_a_at

16792226

204344_PM_s_at

204344_s_at

212887_PM_at

212887_at

3561953

3561954

3561959

3561960

3561961

3561962

3561963

3561964

3561966

3561969

3561970

3561971

3561972

3561973

3561974

3561975

3561977

3561979

3561981

3561983

3561984

3561985

3561986

3561987

3561988

3561989

3561990

3561991

3561992

3561993

3561994

3561996

39099_at

7978718

A_23_P140170

A_23_P348894

GE79967

GO:0000139

GO:0005096

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006886

GO:0006888

GO:0008270

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030127

GO:0030134

GO:0031410

GO:0043226

GO:0046872

GO:0048471

GO:0061024

GO:0070971

GO:0072659

GO:0090110

GO:0090114

GO:0098772

HMNXSV003029895

Hs.321403.0.S1_3p_at

ILMN_1790311

ILMN_2129309

PH_hs_0040483

TC14001063.hg

X97064_at

g5454041_3p_s_at

Participates

as an output of

CSNK1D phosphorylates SEC23 (Homo sapiens)

Other forms of this molecule

SEC23A [endoplasmic reticulum membrane]

SEC23A [cytosol]

SEC23A [ER to Golgi transport vesicle membrane]

Inferred To

phospho-pfsec23 [cytosol] (Plasmodium falciparum)

phospho-Sec23a [cytosol] (Rattus norvegicus)

phospho-sec-23 [cytosol] (Caenorhabditis elegans)

phospho-SEC23A [cytosol] (Bos taurus)

phospho-SEC23A [cytosol] (Canis familiaris)

phospho-SEC23A [cytosol] (Gallus gallus)

phospho-SEC23A [cytosol] (Sus scrofa)

phospho-sec23 [cytosol] (Dictyostelium discoideum)

phospho-Sec23 [cytosol] (Drosophila melanogaster)

phospho-p-S738,T744 SEC23A [cytosol] (Mus musculus)

phospho-p-S738,T744 SEC23A [cytosol] (Saccharomyces cerevisiae)

phospho-p-S738,T744 SEC23A [cytosol] (Schizosaccharomyces pombe)

phospho-p-S738,T744 SEC23A [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 738

Coordinate

738

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 744

Coordinate

744

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_006355.2

OpenTargets

ENSG00000100934

ENSEMBL

ENST00000537403, ENSP00000306881, ENST00000307712, ENSP00000444193

HPA

ENSG00000100934-SEC23A

PRO

Q15436

Pharos - Targets

Q15436

GlyGen

Q15436

Orphanet

SEC23A

PDB

3EGX, 2NUP, 5VNE, 5VNF, 3EFO, 8HR0, 5VNO, 5VNG, 5VNH, 5VNN, 5VNM, 3EG9, 5VNJ, 5VNI, 5KYU, 5VNK, 5VNL, 2NUT, 5KYN, 5KYW, 5KYX, 2YRC, 3EGD, 5KYY, 2YRD

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53992 SEC24C	4	p-SEC24C [cytosol] (R-HSA-5694551) SEC24C [ER to Golgi transport vesicle membrane] (R-HSA-204026) SEC24C [cytosol] (R-HSA-203988) SEC24C [endoplasmic reticulum membrane] (R-HSA-203987)	0.811	8
UniProt:O94855 SEC24D	4	p-SEC24D [cytosol] (R-HSA-5694554) SEC24D [ER to Golgi transport vesicle membrane] (R-HSA-204020) SEC24D [cytosol] (R-HSA-203990) SEC24D [endoplasmic reticulum membrane] (R-HSA-204004)	0.688	5
UniProt:O95487 SEC24B	4	p-SEC24B [cytosol] (R-HSA-5685746) SEC24B [ER to Golgi transport vesicle membrane] (R-HSA-204021) SEC24B [cytosol] (R-HSA-204001) SEC24B [endoplasmic reticulum membrane] (R-HSA-203982)	0.669	4
UniProt:Q15437 SC23B			0.666	6
UniProt:Q9Y6Y8 SEC23IP	2	SEC23IP [cytosol] (R-HSA-5688156) SEC23IP [COPII-coated ER to Golgi transport vesicle] (R-HSA-5688153)	0.666	5
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981)	0.636	3
UniProt:Q00536 CDK16			0.581	3
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.556	3
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.556	3
UniProt:Q5JRA6 MIA3	3	MIA3 [endoplasmic reticulum membrane] (R-HSA-5689472) p-MIA3 [endoplasmic reticulum lumen] (R-HSA-8957064) MIA3 [endoplasmic reticulum lumen] (R-HSA-8956743)	0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q969F0 FATE1			0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.556	3
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q12983 BNIP3			0.556	3
UniProt:Q9UPX6 MNAR1			0.556	3
UniProt:Q96B21 TM45B			0.556	3
UniProt:O43557 TNFSF14	1	TNFSF14 [plasma membrane] (R-HSA-5667149)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:A2RRN7 A2RRN7			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:Q6ZS10 CL17A			0.556	3
UniProt:Q9GZY8-5 MFF			0.556	3
UniProt:Q15637-4 SF1			0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.556	3
UniProt:Q9P2R7 SUCLA2	1	SUCLA2 [mitochondrial matrix] (R-HSA-156624)	0.556	3
UniProt:O94855-2 SEC24D			0.556	3
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:Q96M27 PRRC1			0.527	3
UniProt:O95486 SEC24A	4	p-SEC24A [cytosol] (R-HSA-5685743) SEC24A [ER to Golgi transport vesicle membrane] (R-HSA-204022) SEC24A [cytosol] (R-HSA-203978) SEC24A [endoplasmic reticulum membrane] (R-HSA-203992)	0.527	3
UniProt:O94979 SEC31A	5	SEC31A [ER to Golgi transport vesicle membrane] (R-HSA-204010) SEC31A [cytosol] (R-HSA-203983) SEC31A [endoplasmic reticulum membrane] (R-HSA-204000) SEC31A(1-989)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713478) SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713475)	0.508	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.499	20
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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