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p-S738,T744 SEC23A [cytosol]
Stable Identifier
R-HSA-5685740
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein transport protein Sec23A, S23A_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q86UW9 DTX2
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
p-S738,T744 SEC23A [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
p-S738,T744 SEC23A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15436 SEC23A
Gene Names
SEC23A
Chain
initiator methionine:, chain:2-765
Reference Genes
BioGPS Gene:10484 SEC23A
COSMIC (genes):SEC23A SEC23A
CTD Gene:10484 SEC23A
dbSNP Gene:10484 SEC23A
ENSEMBL:ENSG00000100934 SEC23A
ENSEMBL_homo_sapiens_GENE:ENSG00000100934.15 SEC23A
HGNC:10701 SEC23A
KEGG Gene (Homo sapiens):10484 SEC23A
Monarch:10484 SEC23A
NCBI Gene:10484 SEC23A
OMIM:610511 SEC23A
UCSC:Q15436 SEC23A
Reference Transcript
RefSeq:NM_006364.3 SEC23A
Other Identifiers
10484
11722354_at
11747925_a_at
11749485_x_at
11752872_a_at
16792226
204344_PM_s_at
204344_s_at
212887_PM_at
212887_at
3561953
3561954
3561959
3561961
3561963
3561964
3561966
3561969
3561970
3561971
3561974
3561975
3561977
3561979
3561981
3561983
3561984
3561985
3561986
3561990
3561992
3561993
3561994
3561996
39099_at
7978718
A_23_P140170
A_23_P348894
GE79967
GO:0000139
GO:0005096
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006886
GO:0006888
GO:0008270
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0030127
GO:0030134
GO:0031410
GO:0043226
GO:0046872
GO:0048471
GO:0061024
GO:0070971
GO:0072659
GO:0090110
GO:0090114
GO:0098772
HMNXSV003029895
Hs.321403.0.S1_3p_at
ILMN_1790311
ILMN_2129309
PH_hs_0040483
TC14001063.hg
X97064_at
g5454041_3p_s_at
Participates
as an output of
CSNK1D phosphorylates SEC23 (Homo sapiens)
Other forms of this molecule
SEC23A [ER to Golgi transport vesicle membrane]
SEC23A [cytosol]
SEC23A [endoplasmic reticulum membrane]
Inferred To
phospho-pfsec23 [cytosol]
(Plasmodium falciparum)
phospho-Sec23a [cytosol]
(Rattus norvegicus)
phospho-sec-23 [cytosol]
(Caenorhabditis elegans)
phospho-SEC23A [cytosol]
(Bos taurus)
phospho-SEC23A [cytosol]
(Canis familiaris)
phospho-SEC23A [cytosol]
(Gallus gallus)
phospho-SEC23A [cytosol]
(Sus scrofa)
phospho-sec23 [cytosol]
(Dictyostelium discoideum)
phospho-Sec23 [cytosol]
(Drosophila melanogaster)
phospho-p-S738,T744 SEC23A [cytosol]
(Mus musculus)
phospho-p-S738,T744 SEC23A [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S738,T744 SEC23A [cytosol]
(Schizosaccharomyces pombe)
phospho-p-S738,T744 SEC23A [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 738
Coordinate
738
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 744
Coordinate
744
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_006355.2
OpenTargets
ENSG00000100934
GeneCards
Q15436
HPA
ENSG00000100934-SEC23A
Ensembl
ENSP00000444193
,
ENST00000537403
,
ENST00000307712
,
ENSG00000100934
,
ENSP00000306881
PRO
Q15436
Pharos - Targets
Q15436
Orphanet
15265
PDB
5VNH
,
5KYX
,
2NUT
,
3EFO
,
5VNI
,
5KYY
,
5VNJ
,
3EG9
,
8HR0
,
5VNK
,
2NUP
,
5VNL
,
2YRC
,
5VNM
,
5VNN
,
2YRD
,
3EGD
,
5KYN
,
5VNO
,
5VNE
,
5KYU
,
5VNF
,
3EGX
,
5VNG
,
5KYW
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53992 SEC24C
4
p-SEC24C [cytosol]
(R-HSA-5694551)
SEC24C [ER to Golgi transport vesicle membrane]
(R-HSA-204026)
SEC24C [cytosol]
(R-HSA-203988)
SEC24C [endoplasmic reticulum membrane]
(R-HSA-203987)
0.811
8
UniProt:O94855 SEC24D
4
p-SEC24D [cytosol]
(R-HSA-5694554)
SEC24D [ER to Golgi transport vesicle membrane]
(R-HSA-204020)
SEC24D [cytosol]
(R-HSA-203990)
SEC24D [endoplasmic reticulum membrane]
(R-HSA-204004)
0.688
5
UniProt:O95487 SEC24B
4
p-SEC24B [cytosol]
(R-HSA-5685746)
SEC24B [ER to Golgi transport vesicle membrane]
(R-HSA-204021)
SEC24B [cytosol]
(R-HSA-204001)
SEC24B [endoplasmic reticulum membrane]
(R-HSA-203982)
0.669
4
UniProt:Q9Y6Y8 SEC23IP
2
SEC23IP [cytosol]
(R-HSA-5688156)
SEC23IP [COPII-coated ER to Golgi transport vesicle]
(R-HSA-5688153)
0.666
5
UniProt:Q15437 SC23B
0.666
6
UniProt:P55735 SEC13
4
SEC13 [lysosomal membrane]
(R-HSA-9638246)
SEC13 [ER to Golgi transport vesicle membrane]
(R-HSA-204012)
SEC13 [cytosol]
(R-HSA-203981)
SEC13 [endoplasmic reticulum membrane]
(R-HSA-203994)
0.636
3
UniProt:Q00536 CDK16
0.581
3
UniProt:O94855-2 SEC24D
0.556
3
UniProt:Q9P2R7 SUCLA2
1
SUCLA2 [mitochondrial matrix]
(R-HSA-156624)
0.556
3
UniProt:O75477 ERLIN1
1
ERLIN1 [endoplasmic reticulum membrane]
(R-HSA-8866518)
0.556
3
UniProt:P48165 GJA8
1
GJA8 [endoplasmic reticulum membrane]
(R-HSA-190702)
0.556
3
UniProt:Q15637-4 SF1
0.556
3
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:Q6ZS10 CL17A
0.556
3
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.556
3
UniProt:A2RRN7 A2RRN7
0.556
3
UniProt:O75928-2 PIAS2
1
PIAS2-2 [nucleoplasm]
(R-HSA-2993779)
0.556
3
UniProt:O43557 TNFSF14
1
TNFSF14 [plasma membrane]
(R-HSA-5667149)
0.556
3
UniProt:Q96B21 TM45B
0.556
3
UniProt:Q9UPX6 MNAR1
0.556
3
UniProt:Q12983 BNIP3
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.556
3
UniProt:Q9Y2W2 WBP11
1
WBP11 [nucleoplasm]
(R-HSA-8867887)
0.556
3
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.556
3
UniProt:Q969F0 FATE1
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:Q5JRA6 MIA3
3
MIA3 [endoplasmic reticulum membrane]
(R-HSA-5689472)
p-MIA3 [endoplasmic reticulum lumen]
(R-HSA-8957064)
MIA3 [endoplasmic reticulum lumen]
(R-HSA-8956743)
0.556
3
UniProt:Q14203-5 DCTN1
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.556
3
UniProt:O95486 SEC24A
4
SEC24A [endoplasmic reticulum membrane]
(R-HSA-203992)
SEC24A [cytosol]
(R-HSA-203978)
SEC24A [ER to Golgi transport vesicle membrane]
(R-HSA-204022)
p-SEC24A [cytosol]
(R-HSA-5685743)
0.527
3
UniProt:Q96M27 PRRC1
0.527
3
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
2
UniProt:O94979 SEC31A
5
SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713475)
SEC31A(1-989)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713478)
SEC31A [ER to Golgi transport vesicle membrane]
(R-HSA-204010)
SEC31A [endoplasmic reticulum membrane]
(R-HSA-204000)
SEC31A [cytosol]
(R-HSA-203983)
0.508
2
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.499
20
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
10
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