Reactome | NAPSA, CTSH, PGA3-5 cleave pro-SFTPC

NAPSA, CTSH, PGA3-5 cleave pro-SFTPC

Stable Identifier

R-HSA-5685902

Type

Reaction [transition]

Species

Homo sapiens

Compartment

multivesicular body lumen

ReviewStatus

5/5

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In the multivesicular body, surfactant precursor protein pro-SFTPC is most likely proteolytically cleaved by napsin-A (NAPSA), cathepsin-H (CTSH) and pepsinogens 3-5 (PGA3-5) (Chuman et al. 1999, Fuchs & Gassen 1989, Athauda et al. 1989, Johansson et al. 1988). The resultant mature peptide SFTPC (chain 24-58) is trafficked to lamellar bodies.

Literature References

PubMed ID	Title	Journal	Year
2515193	A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins Takahashi, K, Kageyama, T, Athauda, SB, Tanji, M	J. Biochem.	1989
2587265	Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase Gassen, HG, Fuchs, R	Nucleic Acids Res.	1989
3366248	Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms Johansson, J, Robertson, B, Jörnvall, H, Christensen, N, Eklund, A, Curstedt, T	FEBS Lett.	1988
10580105	Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas Arnott, D, Ueno, T, Saito, S, Bergman, T, Appella, E, Bergman, A, Auer, G, Sakaguchi, K, Chuman, Y, Alaiya, AA, Jörnvall, H, Linder, S, Franzén, B	FEBS Lett.	1999