Reactome | SLX1A [nucleoplasm]

SLX1A [nucleoplasm]

Stable Identifier

R-HSA-5686481

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Structure-specific endonuclease subunit SLX1, SLX1, SLX1B, GIYD2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BQ83 SLX1A

Gene Names

SLX1A, GIYD1, SLX1, SLX1B, GIYD2, SLX1

Chain

chain:1-275

Reference Genes

BioGPS Gene:548593 SLX1A

BioGPS Gene:79008 SLX1A

COSMIC (genes):SLX1A SLX1A

COSMIC (genes):SLX1B SLX1A

CTD Gene:548593 SLX1A

CTD Gene:79008 SLX1A

dbSNP Gene:548593 SLX1A

dbSNP Gene:79008 SLX1A

ENSEMBL:ENSG00000132207 SLX1A

ENSEMBL:ENSG00000181625 SLX1A

HGNC:20922 SLX1A

HGNC:28748 SLX1A

KEGG:hsa:548593 SLX1A

KEGG:hsa:79008 SLX1A

Monarch:548593 SLX1A

Monarch:79008 SLX1A

NCBI Gene:548593 SLX1A

NCBI Gene:79008 SLX1A

OMIM:615822 SLX1A

OMIM:615823 SLX1A

UCSC:Q9BQ83 SLX1A

Reference Transcript

Other Identifiers

11722692_x_at

11742399_s_at

130134321

16817603

218317_PM_x_at

218317_x_at

222094_PM_at

222094_at

233334_PM_x_at

233334_x_at

3655451

3655452

3655453

3655454

3655455

3655457

3655458

3655459

3655460

3655461

3655462

3655463

3655464

3655465

3656033

3656034

3656035

3656036

3656037

3656039

3656040

3656041

3656042

3656043

3656044

3656045

3656046

3656047

548593

64454_at

79008

80466_s_at

A_23_P501451

A_24_P914573

GE82771

GO:0000724

GO:0003824

GO:0004519

GO:0005515

GO:0005634

GO:0005654

GO:0006281

GO:0006310

GO:0008821

GO:0010792

GO:0010833

GO:0016787

GO:0017108

GO:0032200

GO:0033557

GO:0043226

GO:0046872

GO:0061820

GO:0090656

GO:0140097

GO:1904357

GO:1904431

HMNXSV003019181

ILMN_1656382

ILMN_1664993

ILMN_1670517

ILMN_1703894

ILMN_1776527

ILMN_2262177

ILMN_2272708

ILMN_2368575

g13129003_3p_a_at

g13129003_3p_s_at

Participates

as a component of

SLX1A:SLX4 [nucleoplasm] (Homo sapiens)

Inferred To

slx1 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SLX1A [nucleoplasm] (Gallus gallus)

SLX1A [nucleoplasm] (Bos taurus)

SLX1A [nucleoplasm] (Canis familiaris)

SLX1A [nucleoplasm] (Sus scrofa)

Slx1b [nucleoplasm] (Mus musculus)

Slx1b [nucleoplasm] (Rattus norvegicus)

slx1a [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_076949.1, NP_001015000.1, NP_001014999.1, NP_835145.1

OpenTargets

ENSG00000132207, ENSG00000181625

ENSEMBL

ENSG00000132207, ENST00000251303, ENST00000345535, ENSP00000328940, ENSP00000251303, ENSG00000181625, ENSP00000335316, ENST00000330181, ENSP00000333945, ENST00000351581

HPA

ENSG00000181625-SLX1B, ENSG00000132207-SLX1A

GeneCards

SLX1A, SLX1B

PRO

Q9BQ83

Pharos - Targets

Q9BQ83

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.564	2
UniProt:O14867 BACH1	5	BACH1 [nucleoplasm] (R-HSA-9707688) BACH1 [cytosol] (R-HSA-9708429) PolyUb-BACH1 [nucleoplasm] (R-HSA-9708486) p-Y483 BACH1 [nucleoplasm] (R-HSA-9762202) p-Y483 BACH1 [cytosol] (R-HSA-9762206)	0.527	2
UniProt:P27540 ARNT	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.527	2
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.527	2
UniProt:Q96NY9 MUS81	1	MUS81 [nucleoplasm] (R-HSA-5686443)	0.527	2
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	2
UniProt:P07992 ERCC1	2	ERCC1 [nucleoplasm] (R-HSA-54427) Ub-ERCC1 [nucleoplasm] (R-HSA-5696473)	0.527	2