ATM, activated in response to DNA damage in the form of double-strand breaks, phosphorylates ABL1 (c-ABL) on serine residue S456, resulting in the activation of kinase activity of ABL1 (Baskaran et al. 1997).
Morgan, SE, Kastan, MB, Wynshaw-Boris, A, Wang, JY, Baltimore, D, Barlow, C, Baskaran, R, Canman, CE, Wood, LD, Xu, Y, Whitaker, LL
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
© 2023 Reactome
