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About
What is Reactome ?
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Digital Preservation
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Table of Contents
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ABL1 [nucleoplasm]
Stable Identifier
R-HSA-5686579
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proto-oncogene tyrosine-protein kinase ABL1, ABL1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
Activated ATM phosphorylates ABL1 (Homo sapiens)
ABL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00519 ABL1
Gene Names
ABL1, ABL, JTK7
Chain
chain:1-1130
Reference Genes
BioGPS Gene:25 ABL1
COSMIC (genes):ABL1 ABL1
CTD Gene:25 ABL1
dbSNP Gene:25 ABL1
ENSEMBL:ENSG00000097007 ABL1
ENSEMBL_homo_sapiens_GENE:ENSG00000097007.20 ABL1
HGNC:76 ABL1
KEGG Gene (Homo sapiens):25 ABL1
Monarch:25 ABL1
NCBI Gene:25 ABL1
OMIM:189980 ABL1
UCSC:P00519 ABL1
Reference Transcript
RefSeq:NM_005157.5 ABL1
RefSeq:NM_007313.2 ABL1
Other Identifiers
11717174_a_at
11717175_a_at
11740485_a_at
11757851_s_at
1635_at
1636_g_at
1656_s_at
17090373
202123_PM_s_at
202123_s_at
2040_s_at
2041_i_at
25
3191725
3191726
3191748
3191758
3191759
3191760
3191770
3191774
3191775
3191776
3191777
3191779
3191780
3191782
3191785
3191786
3191787
3191788
3191789
39730_at
52316_s_at
8158725
A_23_P60180
A_24_P281101
A_24_P282416
A_24_P291016
A_24_P393711
GE58357
GO:0000166
GO:0000278
GO:0000287
GO:0000400
GO:0000405
GO:0001726
GO:0001784
GO:0001843
GO:0001922
GO:0001934
GO:0002322
GO:0002333
GO:0002376
GO:0003013
GO:0003677
GO:0003713
GO:0003785
GO:0003824
GO:0004515
GO:0004672
GO:0004713
GO:0004715
GO:0005080
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0006281
GO:0006298
GO:0006310
GO:0006351
GO:0006355
GO:0006468
GO:0006897
GO:0006909
GO:0006914
GO:0006915
GO:0006974
GO:0006979
GO:0007010
GO:0007154
GO:0007155
GO:0007163
GO:0007173
GO:0007204
GO:0007229
GO:0007249
GO:0007611
GO:0008092
GO:0008306
GO:0008630
GO:0009410
GO:0009791
GO:0010506
GO:0010595
GO:0012501
GO:0015629
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016604
GO:0016740
GO:0017124
GO:0018108
GO:0019901
GO:0019904
GO:0019905
GO:0021587
GO:0022408
GO:0023052
GO:0030035
GO:0030036
GO:0030041
GO:0030100
GO:0030145
GO:0030154
GO:0030155
GO:0030182
GO:0030198
GO:0030425
GO:0030426
GO:0030509
GO:0030514
GO:0030516
GO:0031113
GO:0031252
GO:0031965
GO:0032489
GO:0032729
GO:0032743
GO:0032956
GO:0032991
GO:0033690
GO:0034330
GO:0034446
GO:0034599
GO:0034976
GO:0035791
GO:0036211
GO:0038083
GO:0038096
GO:0038189
GO:0038191
GO:0042100
GO:0042127
GO:0042169
GO:0042770
GO:0042981
GO:0043025
GO:0043065
GO:0043123
GO:0043226
GO:0043525
GO:0043542
GO:0043621
GO:0045580
GO:0045907
GO:0045930
GO:0045931
GO:0045944
GO:0046632
GO:0046777
GO:0046872
GO:0046875
GO:0048008
GO:0048146
GO:0048471
GO:0048536
GO:0048538
GO:0048856
GO:0048870
GO:0050731
GO:0050798
GO:0050852
GO:0050853
GO:0050877
GO:0050885
GO:0051015
GO:0051019
GO:0051128
GO:0051281
GO:0051353
GO:0051402
GO:0051444
GO:0051450
GO:0051496
GO:0051649
GO:0051726
GO:0051882
GO:0051894
GO:0055065
GO:0055085
GO:0060020
GO:0060038
GO:0060563
GO:0065003
GO:0070064
GO:0070097
GO:0070301
GO:0070371
GO:0070373
GO:0070374
GO:0071103
GO:0071222
GO:0071560
GO:0071871
GO:0071901
GO:0072359
GO:0090050
GO:0090398
GO:0098609
GO:0098794
GO:0140096
GO:0140110
GO:1900006
GO:1900026
GO:1900272
GO:1900275
GO:1902036
GO:1903053
GO:1903055
GO:1903210
GO:1903351
GO:1903905
GO:1904157
GO:1904518
GO:1904528
GO:1904531
GO:1905244
GO:1905555
GO:1990051
GO:1990837
GO:2000042
GO:2000096
GO:2000145
GO:2000352
GO:2000406
GO:2000772
GO:2000773
HMNXSV003048474
ILMN_1708922
ILMN_1713732
ILMN_2268241
PH_hs_0021950
TC09000741.hg
TC09002302.hg
X16416_at
g6382056_3p_a_at
Participates
as an input of
Activated ATM phosphorylates ABL1 (Homo sapiens)
Other forms of this molecule
p-Y393-ABL1 [cytosol]
p-Y226,Y393-ABL1 [nucleoplasm]
ABL1 [cytosol]
p-Y226,Y393-ABL1 [cytosol]
p-S456-ABL1 [nucleoplasm]
Inferred To
ABL1 [nucleoplasm]
(Bos taurus)
ABL1 [nucleoplasm]
(Caenorhabditis elegans)
ABL1 [nucleoplasm]
(Canis familiaris)
ABL1 [nucleoplasm]
(Drosophila melanogaster)
ABL1 [nucleoplasm]
(Gallus gallus)
ABL1 [nucleoplasm]
(Mus musculus)
ABL1 [nucleoplasm]
(Rattus norvegicus)
ABL1 [nucleoplasm]
(Sus scrofa)
ABL1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005148.2
,
NP_009297.2
ZINC - World Drugs
ABL1_HUMAN
Guide to Pharmacology - Targets
1923
OpenTargets
ENSG00000097007
ZINC - FDA approved
ABL1_HUMAN
ZINC - Substances
ABL1_HUMAN
ZINC target
P00519
ZINC - Biogenic
ABL1_HUMAN
PRO
P00519
PDB
2G1T
,
1AWO
,
2HYY
,
3QRJ
,
2FO0
,
2HZ4
,
4J9G
,
6NPE
,
7PVQ
,
3QRI
,
2E2B
,
3EGU
,
4JJC
,
4JJB
,
2HZI
,
2G2F
,
1BBZ
,
7N9G
,
4TWP
,
5HU9
,
3EG1
,
5DC0
,
6XRG
,
4ZOG
,
7W7X
,
6AMW
,
7PVR
,
4XEY
,
4J9E
,
5OAZ
,
7PVS
,
2V7A
,
3EG2
,
5DC4
,
4J9D
,
3QRK
,
2HIW
,
4J9H
,
4J9I
,
6BL8
,
7CC2
,
6XR6
,
1JU5
,
3T04
,
8SSN
,
3CS9
,
7W7Y
,
8H7F
,
5NP2
,
4WA9
,
8H7H
,
2F4J
,
1OPL
,
3K2M
,
1ZZP
,
7PVV
,
6NPV
,
2G2I
,
2GQG
,
4J9C
,
1AB2
,
3EG0
,
4J9B
,
4JJD
,
2G2H
,
4YC8
,
3PYY
,
4J9F
,
2HZ0
,
6XR7
,
2ABL
,
3UYO
,
5DC9
,
3EG3
,
6AMV
,
5MO4
,
2O88
,
7PW2
,
3UE4
,
7DT2
,
6NPU
ZINC - Investigational
ABL1_HUMAN
ZINC - Metabolites
ABL1_HUMAN
GeneCards
P00519
HPA
ENSG00000097007-ABL1
Ensembl
ENST00000318560
,
ENSP00000323315
,
ENSG00000097007
,
ENST00000372348
,
ENSP00000361423
Pharos - Targets
P00519
Orphanet
15062
ZINC - Predictions - Purchasable
ABL1_HUMAN
HMDB Protein
HMDBP01402
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IZP0 ABI1
2
p-5S-ABI1 [cytosol]
(R-HSA-2029034)
ABI1 [cytosol]
(R-HSA-1671643)
0.9
11
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.889
8
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.827
6
UniProt:O43196 MSH5
1
MSH5 [nucleoplasm]
(R-HSA-912435)
0.819
10
UniProt:Q13671 RIN1
1
RIN1 [cytosol]
(R-HSA-8875287)
0.786
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.763
6
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.744
5
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.743
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.725
4
IntAct:EBI-7094147 P41
0.713
5
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.708
4
UniProt:Q13315 ATM
5
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
ATM [nucleoplasm]
(R-HSA-69484)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [peroxisomal matrix]
(R-HSA-9665169)
ATM [cytosol]
(R-HSA-9665171)
0.704
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.692
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.667
5
UniProt:Q13905 RAPGEF1
2
RAPGEF1 [cytosol]
(R-HSA-913472)
RAPGEF1 [endosome]
(R-HSA-3008667)
0.656
4
UniProt:Q03468 ERCC6
2
Ub-ERCC6 [nucleoplasm]
(R-HSA-6781853)
ERCC6 [nucleoplasm]
(R-HSA-54429)
0.655
8
UniProt:P15941-12 MUC1
0.645
4
UniProt:Q9NYB9 ABI2
2
ABI2 [cytosol]
(R-HSA-1671647)
p-4S-ABI2 [cytosol]
(R-HSA-2029003)
0.641
3
IntAct:EBI-3946155 ABL-TIDE
0.609
5
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.602
3
UniProt:P15498 VAV1
5
p-Y-VAV1 [cytosol]
(R-HSA-9029087)
VAV1 [plasma membrane]
(R-HSA-1045153)
VAV1 [cytosol]
(R-HSA-195066)
p-Y174-VAV1 [cytosol]
(R-HSA-437946)
p-Y142,Y160,Y174-VAV1 [plasma membrane]
(R-HSA-389323)
0.602
5
UniProt:Q9Y4G6 TLN2
0.602
3
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.602
7
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.591
6
UniProt:Q9Y6W5 WASF2
3
WASF2 [cytosol]
(R-HSA-200972)
p-Y150,S343,T346-WASF2 [cytosol]
(R-HSA-2130179)
p-Y150-WASF2 [cytosol]
(R-HSA-2130193)
0.59
2
UniProt:Q38SD2 LRRK1
0.59
3
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.589
2
UniProt:O35158
1
Cdon [plasma membrane]
(R-RNO-197892)
0.581
4
UniProt:Q92918 M4K1
0.573
3
UniProt:Q92558 WASF1
3
WASF1 [cytosol]
(R-HSA-200965)
p-Y151,S,T-WASF1 [cytosol]
(R-HSA-5672390)
p-Y151-WASF1 [cytosol]
(R-HSA-2029058)
0.571
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.558
2
UniProt:P51692 STAT5B
4
STAT5B [cytosol]
(R-HSA-380737)
p-Y699-STAT5B [cytosol]
(R-HSA-507939)
p-Y699-STAT5B [nucleoplasm]
(R-HSA-508016)
p-STAT5B [cytosol]
(R-HSA-8983127)
0.558
2
UniProt:O14672 ADAM10
6
ADAM10(215-824) [plasma membrane]
(R-HSA-179885)
ADAM10 [plasma membrane]
(R-HSA-157237)
ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956768)
p-ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956999)
ADAM10 [tertiary granule membrane]
(R-HSA-6800992)
ADAM10 [specific granule membrane]
(R-HSA-6799566)
0.544
2
UniProt:O60504-2 SORBS3
0.544
5
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.544
2
UniProt:Q15427 SF3B4
1
SF3B4 [nucleoplasm]
(R-HSA-71975)
0.536
2
UniProt:P05107 ITGB2
4
ITGB2 [specific granule membrane]
(R-HSA-6803284)
ITGB2 [ficolin-1-rich granule membrane]
(R-HSA-6803310)
ITGB2 [tertiary granule membrane]
(R-HSA-6803342)
ITGB2 [plasma membrane]
(R-HSA-198010)
0.524
4
UniProt:Q4KMG0 CDON
1
CDON [plasma membrane]
(R-HSA-197892)
0.524
2
UniProt:Q9BX66 SORBS1
1
SORBS1 [cytosol]
(R-HSA-445795)
0.524
2
UniProt:Q15464 SHB
2
SHB [cytosol]
(R-HSA-4420213)
pS-SHB [cytosol]
(R-HSA-5228991)
0.524
5
IntAct:EBI-7319639 P41R
0.508
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.483
2
UniProt:P15941 MUC1
19
MUC1(24-1255) [plasma membrane]
(R-HSA-6793976)
Core 8 (MUC1) [Golgi lumen]
(R-HSA-1462219)
Core 2S (MUC1) [Golgi lumen]
(R-HSA-6786333)
Core 5 (MUC1) [Golgi lumen]
(R-HSA-1462231)
Core 4 (MUC1) [Golgi lumen]
(R-HSA-1462154)
Core 3 (MUC1) [Golgi lumen]
(R-HSA-1462068)
Core 7 (MUC1) [Golgi lumen]
(R-HSA-1462105)
extended Core 6 (MUC1) [Golgi lumen]
(R-HSA-1967019)
Core 6 (MUC1) [Golgi lumen]
(R-HSA-1462085)
MUC1(24-1255) [Golgi lumen]
(R-HSA-913611)
Disialyl T-antigen (MUC1) [Golgi lumen]
(R-HSA-1463518)
Sialyl T-antigen (MUC1) [Golgi lumen]
(R-HSA-1463531)
Sialyl-2,3 T-antigen (MUC1) [Golgi lumen]
(R-HSA-1463483)
T-antigen (MUC1) [Golgi lumen]
(R-HSA-1462359)
Sialyl Tn antigen (MUC1) [Golgi lumen]
(R-HSA-1463526)
GalNAc-MUC1(24-1255) [Golgi lumen]
(R-HSA-913642)
Core 2a (MUC1) [Golgi lumen]
(R-HSA-6784286)
Core 2 (MUC1) [Golgi lumen]
(R-HSA-1462167)
GalNAc-MUC1(24-1255) [plasma membrane]
(R-HSA-8858449)
0.463
4
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