The endonuclease complex ERCC1:XPF (ERCC1:ERCC4) is recruited to single strand annealing (SSA) sites of DNA double-strand break (DSB) repair through direct interaction between XPF (ERCC4) and RAD52 (Motycka et al. 2004). ERCC1:XPF cleaves the ssDNA flaps generated by displacement of non-complementary 3' parts of 3' ssDNA overhangs during RAD52-mediated annealing. The enzymatic activity of ERCC1:XPF is necessary for the completion of SSA (Motycka et al. 2004, Al-Minawi et al. 2008, Ahmad et al. 2008).
van Drunen, E, Ahmad, A, Beverloo, HB, Niedernhofer, LJ, Robinson, AR, Weisberg, DB, Hasty, P, Duensing, A, Hoeijmakers, JH
Saleh-Gohari, N, Helleday, T, Al-Minawi, AZ
Bessho, T, Post, SM, Motycka, TA, Sung, P, Tomkinson, AE
endodeoxyribonuclease activity of ERCC1:ERCC4 [nucleoplasm]
© 2023 Reactome
