Reactome | MAPK4 [cytosol]

MAPK4 [cytosol]

Stable Identifier

R-HSA-5686973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ERK4, PRKM4

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Locations in the PathwayBrowser for interactor UniProt:Q8IW41 MAPKAPK5

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External Reference Information

External Reference

UniProt:P31152 MAPK4

Gene Names

MAPK4, ERK4, PRKM4

Chain

chain:1-587

Reference Genes

BioGPS Gene:5596 MAPK4

COSMIC (genes):MAPK4 MAPK4

CTD Gene:5596 MAPK4

dbSNP Gene:5596 MAPK4

ENSEMBL:ENSG00000141639 MAPK4

HGNC:6878 MAPK4

KEGG:hsa:5596 MAPK4

Monarch:5596 MAPK4

NCBI Gene:5596 MAPK4

OMIM:176949 MAPK4

UCSC:P31152 MAPK4

Reference Transcript

Other Identifiers

11723181_a_at

11751129_a_at

16852322

204707_PM_s_at

204707_s_at

3788098

3788099

3788100

3788103

3788104

3788106

3788107

3788108

3788109

3788110

3788111

3788116

3788123

3788124

3788125

3788126

3788127

3788135

3788140

3788142

3788144

3788145

3788146

3788147

3788148

3788149

3788150

3788151

3788152

3788153

3788154

3788155

3788156

5596

8021199

997_at

A_14_P122275

A_33_P3289860

A_33_P3307337

GE61712

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005770

GO:0005794

GO:0005829

GO:0005901

GO:0005925

GO:0006468

GO:0007173

GO:0010759

GO:0016192

GO:0016301

GO:0016740

GO:0019901

GO:0019902

GO:0032206

GO:0032872

GO:0034198

GO:0035556

GO:0042803

GO:0046982

GO:0051403

GO:0051493

GO:0070849

GO:0072584

GO:0090170

GO:0106310

GO:0120041

GO:0140096

GO:2000641

HMNXSV003012056

HMNXSV003032644

HMNXSV003045922

Hs.269222.0.A1_3p_a_at

ILMN_1669620

ILMN_2112128

PH_hs_0025291

TC18000179.hg

g6715608_3p_a_at

Participates

as an output of

IGF2BP1 represses translation of MAPK4 mRNA (Homo sapiens)

as a member of

MAPK6,4 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S186 MAPK4 [nucleoplasm]

p-S186 MAPK4 [cytosol]

MAPK4 [nucleoplasm]

Inferred To

spm1 [cytosol] (Schizosaccharomyces pombe)

mapk6 [cytosol] (Danio rerio)

MAPK4 [cytosol] (Bos taurus)

MAPK4 [cytosol] (Canis familiaris)

Mapk4 [cytosol] (Mus musculus)

Mapk4 [cytosol] (Rattus norvegicus)

SMK1 [cytosol] (Saccharomyces cerevisiae)

Homologues of MAPK4 [cytosol] (Danio rerio)

Homologues of MAPK4 [cytosol] (Dictyostelium discoideum)

Homologues of MAPK4 [cytosol] (Saccharomyces cerevisiae)

mapk4 [cytosol] (Danio rerio)

mapk4 [cytosol] (Xenopus tropicalis)

cdc7 [cytosol] (Dictyostelium discoideum)

erkA [cytosol] (Dictyostelium discoideum)

SLT2 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_011524377.1, XP_054174785.1, XP_054174784.1, XP_011524378.1, NP_001278969.1, NP_001278968.1, XP_011524376.1, XP_047293581.1, XP_054174786.1, XP_005258356.1, NP_002738.2, XP_054174782.1, XP_016881328.1, XP_054174783.1, XP_054174781.1

ZINC - World Drugs

MK04_HUMAN

Guide to Pharmacology - Targets

2091

OpenTargets

ENSG00000141639

ENSEMBL

ENSP00000383234, ENSG00000141639, ENST00000400384

ZINC - FDA approved

MK04_HUMAN

ZINC - Substances

MK04_HUMAN

ZINC - Biogenic

MK04_HUMAN

ZINC target

P31152

PRO

P31152

ZINC - Investigational

MK04_HUMAN

HPA

ENSG00000141639-MAPK4

GeneCards

MAPK4

Pharos - Targets

P31152

ZINC - Predictions - Purchasable

MK04_HUMAN

HMDB Protein

HMDBP01483

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7L8L6 FASTKD5	1	FASTKD5 [mitochondrial matrix] (R-HSA-9837206)	0.643	4
UniProt:Q8IW41 MAPKAPK5	5	p-T182 MAPKAPK5 [cytosol] (R-HSA-5687004) p-S115 MAPKAPK5 [cytosol] (R-HSA-5687028) p-S115 MAPKAPK5 [nucleoplasm] (R-HSA-5687026) p-T182-MAPKAPK5 [nucleoplasm] (R-HSA-3239018) MAPKAPK5 [nucleoplasm] (R-HSA-2562517)	0.643	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.641	3
UniProt:Q96HN2 AHCYL2	1	AHCYL2 [cytosol] (R-HSA-8878665)	0.527	3
UniProt:Q7Z736 PKHH3			0.527	3
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.527	3
UniProt:Q8IUD2 RB6I2			0.527	2
UniProt:Q01813 PFKP	1	PFKP [cytosol] (R-HSA-71452)	0.527	2
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.527	2

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