Reactome | p-S857 NCOA3 [nucleoplasm]

p-S857 NCOA3 [nucleoplasm]

Stable Identifier

R-HSA-5687005

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor coactivator 3, NCOA3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y6Q9 NCOA3

Gene Names

NCOA3, AIB1, BHLHE42, RAC3, TRAM1

Chain

initiator methionine:, chain:2-1424

Reference Genes

BioGPS Gene:8202 NCOA3

COSMIC (genes):NCOA3 NCOA3

COSMIC (genes):RAC3 NCOA3

COSMIC (genes):TRAM1 NCOA3

CTD Gene:8202 NCOA3

dbSNP Gene:8202 NCOA3

ENSEMBL:ENSG00000124151 NCOA3

HGNC:7670 NCOA3

KEGG:hsa:8202 NCOA3

Monarch:8202 NCOA3

NCBI Gene:8202 NCOA3

OMIM:601937 NCOA3

UCSC:Q9Y6Q9 NCOA3

Reference Transcript

Participates

as an input of

p-S857 NCOA3 binds ETV4 (Homo sapiens)

as a component of

p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)

as an output of

p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)

Other forms of this molecule

NCOA3 [nucleoplasm]

Inferred To

phospho-Ncoa3 [nucleoplasm] (Mus musculus)

phospho-Ncoa3 [nucleoplasm] (Rattus norvegicus)

phospho-p-S857 NCOA3 [nucleoplasm] (Gallus gallus)

phospho-tai [nucleoplasm] (Drosophila melanogaster)

phospho-NCOA3 [nucleoplasm] (Bos taurus)

phospho-NCOA3 [nucleoplasm] (Canis familiaris)

phospho-NCOA3 [nucleoplasm] (Sus scrofa)

phospho-ncoa3 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 857

Coordinate

857

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

Guide to Pharmacology - Targets

2695

OpenTargets

ENSG00000124151

ENSEMBL

ENSG00000124151, ENSP00000361073, ENSP00000361066, ENST00000371998, ENSP00000361065, ENST00000371997, ENST00000372004

HPA

ENSG00000124151-NCOA3

GeneCards

NCOA3

PRO

Q9Y6Q9

Pharos - Targets

Q9Y6Q9

GlyGen

Q9Y6Q9

PDB

1KBH, 3L3Z, 6ES7, 6SQC, 3L3X

HMDB Protein

HMDBP00026

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.688	4
UniProt:O43791 SPOP	1	SPOP [nucleoplasm] (R-HSA-5635035)	0.632	6
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.623	13
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.602	5
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.581	3
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.564	2
ChEBI:90954 MCB-613			0.558	2
UniProt:Q8VIM5-1 MYOCD			0.544	5
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.536	2
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.527	12
UniProt:Q6PL18 ATAD2	1	ATAD2 [nucleoplasm] (R-HSA-8937250)	0.524	2
UniProt:P48281	2	polySUMO2-VDR [nucleoplasm] (R-MMU-4546376) VDR [nucleoplasm] (R-MMU-375512)	0.508	2
UniProt:P51157 RAB28			0.508	2
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.483	3
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.462	2

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