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p-S857 NCOA3 [nucleoplasm]
Stable Identifier
R-HSA-5687005
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor coactivator 3, NCOA3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3 binds ETV4 (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter (Homo sapiens)
p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
p-S857 NOCA3:ETV4:MMP2,10 genes [nucleoplasm] (Homo sapiens)
p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6Q9 NCOA3
Gene Names
NCOA3, AIB1, BHLHE42, RAC3, TRAM1
Chain
initiator methionine:1, chain:2-1424
Reference Genes
BioGPS Gene:8202 NCOA3
COSMIC (genes):NCOA3 NCOA3
CTD Gene:8202 NCOA3
dbSNP Gene:8202 NCOA3
ENSEMBL:ENSG00000124151 NCOA3
ENSEMBL:ENSG00000124151.19 NCOA3
HGNC:7670 NCOA3
KEGG Gene (Homo sapiens):8202 NCOA3
Monarch:8202 NCOA3
NCBI Gene:8202 NCOA3
OMIM:601937 NCOA3
UCSC:Q9Y6Q9 NCOA3
Reference Transcript
RefSeq:NM_006534.3 NCOA3
RefSeq:NM_001174088.1 NCOA3
RefSeq:NM_181659.2 NCOA3
Other Identifiers
11721401_a_at
11721402_a_at
11721403_s_at
11721404_s_at
11721405_s_at
11752022_s_at
11758328_s_at
16914509
207700_PM_s_at
207700_s_at
209060_PM_x_at
209060_x_at
209061_PM_at
209061_at
209062_PM_x_at
209062_x_at
211352_PM_s_at
211352_s_at
33381_at
3887636
3887655
3887661
3887664
3887665
3887666
3887668
3887669
3887670
3887671
3887674
3887675
3887676
3887677
3887678
3887679
3887680
3887681
3887682
3887683
3887684
3887685
3887686
3887688
3887689
3887690
3887691
3887693
3887694
3887695
3887696
3887697
3887698
3887699
3887701
3887702
3887703
3887704
3887705
3887706
3887707
3887708
3887709
3887710
3887711
3887716
3887717
50379_at
8063211
8202
A_14_P129385
A_14_P135867
A_23_P120442
A_23_P313560
A_23_P313568
GE56107
GO:0000785
GO:0000993
GO:0003713
GO:0003824
GO:0004402
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0016740
GO:0016746
GO:0016922
GO:0023052
GO:0030154
GO:0030374
GO:0032870
GO:0032991
GO:0035624
GO:0043226
GO:0043697
GO:0045618
GO:0045944
GO:0046966
GO:0046983
GO:0048856
GO:0060090
GO:0061629
GO:0070062
GO:0071392
GO:0097718
GO:0140096
GO:0140110
GO:1902459
GO:2000035
HMNXSV003035886
Hs.225977.1.A2_3p_a_at
Hs.225977.1.A4_3p_at
ILMN_1708805
ILMN_2347693
PH_hs_0024353
TC20000372.hg
g2318005_3p_a_at
g2565049_3p_a_at
g5729725_3p_a_at
Participates
as an input of
p-S857 NCOA3 binds ETV4 (Homo sapiens)
as a component of
p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)
as an output of
p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)
Other forms of this molecule
NCOA3 [nucleoplasm]
Inferred To
phospho-Ncoa3 [nucleoplasm]
(Mus musculus)
phospho-Ncoa3 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S857 NCOA3 [nucleoplasm]
(Canis familiaris)
phospho-p-S857 NCOA3 [nucleoplasm]
(Danio rerio)
phospho-p-S857 NCOA3 [nucleoplasm]
(Gallus gallus)
phospho-tai [nucleoplasm]
(Drosophila melanogaster)
phospho-NCOA3 [nucleoplasm]
(Bos taurus)
phospho-NCOA3 [nucleoplasm]
(Sus scrofa)
phospho-ncoa3 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 857
Coordinate
857
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_858045.1
,
NP_006525.2
,
NP_001167559.1
Guide to Pharmacology - Targets
2695
OpenTargets
ENSG00000124151
GeneCards
Q9Y6Q9
HPA
ENSG00000124151-NCOA3
Ensembl
ENST00000371998
,
ENST00000371997
,
ENST00000372004
,
ENSP00000361073
,
ENSG00000124151
,
ENSP00000361065
,
ENSP00000361066
PRO
Q9Y6Q9
Pharos - Targets
Q9Y6Q9
Orphanet
25755
HMDB Protein
HMDBP00026
PDB
6SQC
,
3L3X
,
6ES7
,
1KBH
,
3L3Z
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.688
4
UniProt:O43791 SPOP
1
SPOP [nucleoplasm]
(R-HSA-5635035)
0.632
6
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.623
13
UniProt:P61289 PSME3
2
PSME3 [nucleoplasm]
(R-HSA-174310)
PSME3 [cytosol]
(R-HSA-68816)
0.602
5
UniProt:P28065 PSMB9
2
PSMB9 [nucleoplasm]
(R-HSA-174334)
PSMB9 [cytosol]
(R-HSA-68765)
0.581
3
UniProt:P10276 RARA
3
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
RARA [nucleoplasm]
(R-HSA-446164)
0.564
2
ChEBI:90954 MCB-613
0.558
2
UniProt:Q8VIM5-1 MYOCD
0.544
5
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.536
2
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.527
12
UniProt:Q6PL18 ATAD2
1
ATAD2 [nucleoplasm]
(R-HSA-8937250)
0.524
2
UniProt:P51157 RAB28
0.508
2
UniProt:P48281
2
polySUMO2-VDR [nucleoplasm]
(R-MMU-4546376)
VDR [nucleoplasm]
(R-MMU-375512)
0.508
2
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
0.483
3
UniProt:Q92731 ESR2
5
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.462
2
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