MAPK6 is ubiquitinated at the N-terminal

Stable Identifier
R-HSA-5687081
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MAPK6 is ubiquitinated at the N-terminal
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MAPK6 is an unstable protein that is constitutively degraded by the ubiquitin-proteasome system. Degradation is promoted by two destabilization regions in the N-terminal region of MAPK6 which are required for the conjugation of ubiquitin to the free amino-terminal by an unknown ligase (Coulombe et al, 2003; Coulombe et al, 2004). Although in this reaction ubiquitination is depicted as occuring in the cytosol, it may also occur in the nucleus.
Literature References
PubMed ID Title Journal Year
15226418 N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome

Meloche, S, Rodier, G, Coulombe, P, Bonneil, E, Thibault, P

Mol. Cell. Biol. 2004
12808096 Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation

Meloche, S, Rodier, G, Coulombe, P, Pelletier, S, Pellerin, J

Mol. Cell. Biol. 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of unknown ubiquitin ligase [cytosol]

Physical Entity
unknown ubiquitin ligase [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Authored
Rothfels, K  (2015-03-30)
Reviewed
Moens, U  (2015-04-24)
Soulez, M  (2015-05-12)
Mathien, S  (2015-05-12)
Seternes, OM  (2015-05-05)
Meloche, S  (2015-05-12)
Created
Rothfels, K  (2015-04-06)
Cite Us!