MAPK6 is proposed to phosphorylate NCOA3 at serine 857. This phosphorylation is required for NCOA3 to interact with the transcription factor ETV4 (also known as PEA3). Together, ETV4 and NCOA3 bind to the promoters and regulate the expression of metalloprotease genes such as MMP2 and MMP10 and in this way contribute to cell motility and invasiveness in lung cancer (Long et al, 2012; Qin et al, 2008; Yan et al, 2008; Li et al, 2008; reviewed in Kostenko et al, 2012).
Dumitriu, G, Kostenko, S, Moens, U
Erdem, H, Tsai, SY, Yan, J, Li, R, Tsai, MJ, Ittmann, M, Ayala, G, Cai, Y, Yu-Lee, LY
O'Malley, BW, Foulds, CE, Tsai, SY, Liu, J, Long, W, Tsai, MJ, Wistuba, II, Lonard, DM, Ding, C, Qin, J, Qin, J, Solis, LM
Louie, MC, Zou, JX, Li, LB, Chen, HW
O'Malley, BW, Redmond, A, Yuan, Y, Chen, H, Qin, L, Xu, J, Young, L, Liao, L
protein serine/threonine kinase activity of p-S189 MAPK6 [nucleoplasm]
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