Reactome | p-T182 MAPKAPK5 phosphorylates FOXO3

p-T182 MAPKAPK5 phosphorylates FOXO3

Stable Identifier

R-HSA-5687101

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated MAPKAPK5 phosphorylates FOXO3 at serine 215, promoting its activation and translocation to the nucleus. In the nucleus, FOXO3 promotes the expression of miR-34B and C, which in turn represses translation of MYC RNA (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22800433	Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 Dumitriu, G, Kostenko, S, Moens, U	J Mol Signal	2012
21329882	The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis Kress, TR, Eilers, M, Roepman, P, Bushell, M, Samans, B, Cannell, IG, Rosenwald, A, Gaestel, M, Burgering, BM, Brenkman, AB	Mol. Cell	2011
21329875	More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer Myant, K, Sansom, OJ	Mol. Cell	2011