Despite differences in their overall cellular distribution (MAPK6 is found in both the nucleus and the cytosol, while MAPK4 is predominantly found in the cytosol), both MAPK4 and 6 shuttle between the cytosol and the nucleus. Nuclear import of both proteins occurs through an active temperature sensitive pathway, while nuclear export depends on XPO1 (Aberg et al, 2006; Julien et al, 2003).
Meloche, S, Julien, C, Johansen, B, Aberg, E, Keyse, SM, Perander, M, Seternes, OM
Meloche, S, Julien, C, Coulombe, P
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