Reactome | MAPK4,6 translocate to the cytoplasm

MAPK4,6 translocate to the cytoplasm

Stable Identifier

R-HSA-5687109

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Despite differences in their overall cellular distribution (MAPK6 is found in both the nucleus and the cytosol, while MAPK4 is predominantly found in the cytosol), both MAPK4 and 6 shuttle between the cytosol and the nucleus. Nuclear import of both proteins occurs through an active temperature sensitive pathway, while nuclear export depends on XPO1 (Aberg et al, 2006; Julien et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
16971392	Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4 Aberg, E, Perander, M, Johansen, B, Julien, C, Meloche, S, Keyse, SM, Seternes, OM	J. Biol. Chem.	2006
12915405	Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression Julien, C, Coulombe, P, Meloche, S	J. Biol. Chem.	2003