Reactome | MAPK6 is degraded by the 26S proteasome

MAPK6 is degraded by the 26S proteasome

Stable Identifier

R-HSA-5687112

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MAPK6 is a short-lived protein with a half-life of 30 minutes in proliferating cells. Turnover is promoted by the conjugation of ubiquitin to the free amino terminal by an unknown ligase and subsequent degradation by the 26 S proteasome (Coulombe et al, 2003; Coulombe et al, 2004). Ubiquitination and degradation of MAPK6 may also occur in the nucleus as well as the cytosol.

Literature References

PubMed ID	Title	Journal	Year
15226418	N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome Coulombe, P, Rodier, G, Bonneil, E, Thibault, P, Meloche, S	Mol. Cell. Biol.	2004
12808096	Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation Coulombe, P, Rodier, G, Pelletier, S, Pellerin, J, Meloche, S	Mol. Cell. Biol.	2003