Reactome | p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol

p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol

Stable Identifier

R-HSA-5687120

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of MAPK6 or 4 to MAPKAPK5 promotes its redistribution to the cytosol. This depends on a functional protein-protein interaction interface between the two proteins. Cytoplasmic translocation of MAPKAPK5 occurs even in the presence of catalytically inactive MAPK6 or MAPK6 and vice versa, MAPK6 and MAPK4 still provoke nuclear exclusion of kinase inactive MAPKAPK5 (Aberg et al, 2006; Seternes et al, 2004; Kant et al, 2006; reviewed in Kostenko et al, 2012). Phosphorylation of MAPK6 or MAPK4 at S189 or S186 respectively, is required for binding and translocation of MAPKAPK5 to the cytosol (Perander et al, 2008; Deleris et al, 2008; De La Mota-Peynado et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
22800433	Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 Dumitriu, G, Kostenko, S, Moens, U	J Mol Signal	2012
16973613	Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5 Kispert, A, Schumacher, S, Kant, S, Kotlyarov, A, Singh, MK, Gaestel, M	J. Biol. Chem.	2006
16971392	Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4 Meloche, S, Julien, C, Johansen, B, Aberg, E, Keyse, SM, Perander, M, Seternes, OM	J. Biol. Chem.	2006
21317288	Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity De la Mota-Peynado, A, Beeser, A, Chernoff, J	J. Biol. Chem.	2011
18720373	Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5 Déléris, P, Rousseau, J, Meloche, S, Rodier, G, Coulombe, P, Tanguay, PL	J. Cell. Physiol.	2008
15577943	Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway Meloche, S, Johansen, B, Morrice, NA, Mikalsen, T, Moens, U, Armstrong, CG, Keyse, SM, Turgeon, B, Michaelsen, E, Seternes, OM	EMBO J.	2004
18248330	The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5 Johansen, B, Aberg, E, Keyse, SM, Perander, M, Dreyer, B, Guldvik, IJ, Seternes, OM, Outzen, H	Biochem. J.	2008