Reactome | p-S MAPKAPK5 phosphorylates HSPB1

p-S MAPKAPK5 phosphorylates HSPB1

Stable Identifier

R-HSA-5687121

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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HSBP1, also known as HSP27, is small actin-binding protein with roles in cytoskeletal regulation as well as other processes. HSBP1 is a substrate for MAPKAPK5 both in vitro and in vivo, and phosphorylation of serine residues stimulates forskolin-induced F-actin rearrangements (Sun et al, 2007; Tak et al, 2007; Gerits et al, 2007; New et al, 1998; Seternes et al, 2004; Kostenko et al, 2009a; Kostenko et al, 2009b; Kostenko et al, 2011a; reviewed in Kostenko et al, 2011b; Kostenko et al, 2012). There are divergent reports about the physiological relevance of HSBP1 phosphorylation on actin polymeriztion and cell motility (Lavoie et al, 1995; Lamalice et al, 2007; Katsogiannou et al, 2014; Rousseau et al, 2000; Doshi et al, 2010; Stohr et al, 2012). Actin cytoskeletal rearrangements through the MAPK4 pathway are controlled in part by the IGF2BP1-mediated downregulation of MAPK4 translation which abrogates MAPKAPK5 activity and HSBP1 phosphorylation (Stohr et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22800433	Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 Kostenko, S, Dumitriu, G, Moens, U	J Mol Signal	2012
25339975	Heat shock protein 27 phosphorylation state is associated with cancer progression Katsogiannou, M, Andrieu, C, Rocchi, P	Front Genet	2014
7799959	Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27 Lavoie, JN, Lambert, H, Hickey, E, Weber, LA, Landry, J	Mol. Cell. Biol.	1995
20734105	Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function Kostenko, S, Shiryaev, A, Gerits, N, Dumitriu, G, Klenow, H, Johannessen, M, Moens, U	Cell. Mol. Life Sci.	2011
17254968	PRAK is essential for ras-induced senescence and tumor suppression Sun, P, Yoshizuka, N, New, L, Moser, BA, Li, Y, Liao, R, Xie, C, Chen, J, Deng, Q, Yamout, M, Dong, MQ, Frangou, CG, Yates, JR, Wright, PE, Han, J	Cell	2007
17395884	Endothelial cell migration during angiogenesis Lamalice, L, Le Boeuf, F, Huot, J	Circ. Res.	2007
19593530	Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology Kostenko, S, Moens, U	Cell. Mol. Life Sci.	2009
17947239	Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5 Gerits, N, Mikalsen, T, Kostenko, S, Shiryaev, A, Johannessen, M, Moens, U	J. Biol. Chem.	2007
20536836	HSPB1, actin filament dynamics, and aging cells Doshi, BM, Hightower, LE, Lee, J	Ann. N. Y. Acad. Sci.	2010
20849292	Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5 Kostenko, S, Shiryaev, A, Dumitriu, G, Gerits, N, Moens, U	J. Recept. Signal Transduct. Res.	2011
17728103	14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization Tak, H, Jang, E, Kim, SB, Park, J, Suk, J, Yoon, YS, Ahn, JK, Lee, JH, Joe, CO	Cell. Signal.	2007
9628874	PRAK, a novel protein kinase regulated by the p38 MAP kinase New, L, Jiang, Y, Zhao, M, Liu, K, Zhu, W, Flood, LJ, Kato, Y, Parry, GC, Han, J	EMBO J.	1998
15577943	Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway Seternes, OM, Mikalsen, T, Johansen, B, Michaelsen, E, Armstrong, CG, Morrice, NA, Turgeon, B, Meloche, S, Moens, U, Keyse, SM	EMBO J.	2004
19166925	PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5 Kostenko, S, Johannessen, M, Moens, U	Cell. Signal.	2009
22279049	IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling Stöhr, N, Köhn, M, Lederer, M, Glass, M, Reinke, C, Singer, RH, Hüttelmaier, S	Genes Dev.	2012