Reactome | p-S115 MAPKAPK5 translocates to the cytosol

p-S115 MAPKAPK5 translocates to the cytosol

Stable Identifier

R-HSA-5687123

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleoplasm

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p-S115 MAPKAPK5 translocates to the cytosol

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PKA-mediated phosphorylation of serine 115 promotes the translocation of MAPKAPK5 to the cytosol (Kostenko et al, 2011a; Gerits et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
20734105	Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function Dumitriu, G, Klenow, H, Kostenko, S, Moens, U, Johannessen, M, Gerits, N, Shiryaev, A	Cell. Mol. Life Sci.	2011
17947239	Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5 Kostenko, S, Mikalsen, T, Moens, U, Johannessen, M, Gerits, N, Shiryaev, A	J. Biol. Chem.	2007