Reactome | p-S215 FOXO3 translocates to the nucleus

p-S215 FOXO3 translocates to the nucleus

Stable Identifier

R-HSA-5687126

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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p-S215 FOXO3 translocates to the nucleus

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MAPKAPK5-dependent phosphorylation of FOXO3 promotes its nuclear localization (Kress et al, 2011). In the nucleus, FOXO3 promotes expression of miR-34B and C and thereby downregulates expression of c-MYC RNA (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22800433	Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 Dumitriu, G, Kostenko, S, Moens, U	J Mol Signal	2012
21329882	The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis Kress, TR, Eilers, M, Roepman, P, Bushell, M, Samans, B, Cannell, IG, Rosenwald, A, Gaestel, M, Burgering, BM, Brenkman, AB	Mol. Cell	2011
21329875	More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer Myant, K, Sansom, OJ	Mol. Cell	2011