Reactome | p-S215 FOXO3 translocates to the nucleus

p-S215 FOXO3 translocates to the nucleus

Stable Identifier

R-HSA-5687126

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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p-S215 FOXO3 translocates to the nucleus

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MAPKAPK5-dependent phosphorylation of FOXO3 promotes its nuclear localization (Kress et al, 2011). In the nucleus, FOXO3 promotes expression of miR-34B and C and thereby downregulates expression of c-MYC RNA (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22800433	Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 Kostenko, S, Dumitriu, G, Moens, U	J Mol Signal	2012
21329882	The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis Kress, TR, Cannell, IG, Brenkman, AB, Samans, B, Gaestel, M, Roepman, P, Burgering, BM, Bushell, M, Rosenwald, A, Eilers, M	Mol. Cell	2011
21329875	More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer Myant, K, Sansom, OJ	Mol. Cell	2011