Reactome | PRKDC phosphorylates DCLRE1C at DNA DSBs

PRKDC phosphorylates DCLRE1C at DNA DSBs

Stable Identifier

R-HSA-5687183

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PRKDC phosphorylates DCLRE1C at DNA DSBs

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PRKDC (DNA-PKcs) phosphorylates DCLRE1C (ARTEMIS) at least on serine residue S516, and this phosphorylation is necessary for the activation of DCLRE1C endonucleolytic activity (Ma et al. 2002, Ma et al. 2005, Soubeyrand et al. 2006) as it relieves an autoinhibitory conformation of DCLRE1C (Niewolik et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16093244	The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis Lieber, MR, Schwarz, K, Lu, H, Pannicke, U, Niewolik, D, Ma, Y	J. Biol. Chem.	2005
16914548	DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs Kulesza, P, Schwarz, K, Lieber, MR, Lu, H, Wang, LC, Pannicke, U, Zandi, E, Niewolik, D, Ma, Y	J. Biol. Chem.	2006
11955432	Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Schwarz, K, Pannicke, U, Lieber, MR, Ma, Y	Cell	2002
16600297	Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin Soubeyrand, S, Dong, F, de Chasseval, R, Pope, L, Haché, RJ, Gosselin, D, de Villartay, JP	J. Mol. Biol.	2006