Reactome | MRN complex binds RBBP8

MRN complex binds RBBP8

Stable Identifier

R-HSA-5687465

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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In G1 phase, RBBP8 (CtIP) homotetramer associates with the MRN complex (MRE11A:RAD50:NBN) at DNA double strand breaks (DSBs) but does not undergo CDK2-mediated phosphorylation and is therefore unable to recruit BRCA1 (Yun et al. 2009). The activation of ATM DNA damage checkpoint is not needed for microhomology-mediated end joining (MMEJ or alt-NHEJ) (Rahal et al. 2010). MMEJ can also be triggered at other stages of the cell cycle, besides G1, when the amount of DNA DSBs overwhelms high fidelity DNA repair machinery (Liang et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16012167	Modulation of DNA end joining by nuclear proteins Liang, L, Deng, L, Chen, Y, Li, GC, Shao, C, Tischfield, JA	J. Biol. Chem.	2005
20647759	ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining Rahal, EA, Henricksen, LA, Li, Y, Williams, RS, Tainer, JA, Dixon, K	Cell Cycle	2010
19357644	CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle Yun, MH, Hiom, K	Nature	2009