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POLQ homodimer [nucleoplasm]
Stable Identifier
R-HSA-5687515
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
POLQ homodimer [nucleoplasm] (Homo sapiens)
POLQ homodimer [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
POLQ homodimer [nucleoplasm] (Homo sapiens)
POLQ homodimer [nucleoplasm] (Homo sapiens)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
POLQ homodimer [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
POLQ homodimer [nucleoplasm] (Homo sapiens)
POLQ homodimer [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25643323
Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase ?
McDevitt, SM
,
Chandramouly, G
,
Kent, T
,
Ozdemir, AY
,
Pomerantz, RT
Nat. Struct. Mol. Biol.
2015
Participants
components
x 2
POLQ [nucleoplasm]
(Homo sapiens)
Participates
as an input of
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)
as a component of
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
as an output of
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
Inferred To
POLQ homodimer [nucleoplasm]
(Bos taurus)
POLQ homodimer [nucleoplasm]
(Caenorhabditis elegans)
POLQ homodimer [nucleoplasm]
(Canis familiaris)
POLQ homodimer [nucleoplasm]
(Drosophila melanogaster)
POLQ homodimer [nucleoplasm]
(Gallus gallus)
POLQ homodimer [nucleoplasm]
(Mus musculus)
POLQ homodimer [nucleoplasm]
(Rattus norvegicus)
POLQ homodimer [nucleoplasm]
(Sus scrofa)
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