Reactome | PPP4C:PPP4R2 dephosphorylates RPA2

PPP4C:PPP4R2 dephosphorylates RPA2

Stable Identifier

R-HSA-5687758

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The protein serine/threonine phosphatase complex composed of a catalytic subunit PPP4C (PP4C) and a regulatory subunit PPP4R2 (PP4R2) dephosphorylates serine S33 of the RPA2 subunit of the RPA heterotrimer. By regulating the availability of unphosphorylated RPA2, PPP4C:PPP4R2 phosphatase regulates the progression of the homologous recombination repair of DNA double-strand breaks and the duration of ATR checkpoint signaling (Lee et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20154705	A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination Lee, DH, Borowiec, JA, Chowdhury, D, Pan, Y, Kanner, S, Sung, P	Nat. Struct. Mol. Biol.	2010