Reactome | SIRT4 [mitochondrial matrix]

SIRT4 [mitochondrial matrix]

Stable Identifier

R-HSA-5687775

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

fullName evidence="1"NAD-dependent protein deacetylase sirtuin-4 ecNumber evidence="1"3.5.1.-/ecNumber, SIR4_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism (Homo sapiens)
    - Regulation of pyruvate metabolism (Homo sapiens)
      - Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
        
        SIRT4 cleaves lipoyl from DLAT (Homo sapiens)
        
        SIRT4:Zn2+ [mitochondrial matrix] (Homo sapiens)
        
        SIRT4 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6E7 SIRT4

Gene Names

SIRT4, SIR2L4

Chain

transit peptide:1-28, chain:29-314

Reference Genes

BioGPS Gene:23409 SIRT4

COSMIC (genes):SIRT4 SIRT4

CTD Gene:23409 SIRT4

dbSNP Gene:23409 SIRT4

ENSEMBL:ENSG00000089163 SIRT4

HGNC:14932 SIRT4

KEGG:hsa:23409 SIRT4

Monarch:23409 SIRT4

NCBI Gene:23409 SIRT4

OMIM:604482 SIRT4

UCSC:Q9Y6E7 SIRT4

Reference Transcript

Other Identifiers

11728178_at

16757873

220047_PM_at

220047_at

222248_PM_s_at

222248_s_at

23409

3434310

3434312

3434313

3434314

3434315

3434316

3434317

3434319

3434320

3434321

3434322

3434323

45696_at

7959148

A_23_P99226

GE58474

GO:0000820

GO:0003824

GO:0003950

GO:0004407

GO:0005515

GO:0005739

GO:0005743

GO:0005759

GO:0006520

GO:0006541

GO:0006974

GO:0007005

GO:0008270

GO:0010667

GO:0016740

GO:0016747

GO:0016757

GO:0016779

GO:0034979

GO:0034983

GO:0046322

GO:0046676

GO:0046872

GO:0046889

GO:0051287

GO:0061690

GO:0070403

GO:0071456

GO:0072350

GO:0106419

GO:0106420

GO:0140096

GO:0140803

GO:0160218

GO:1903217

GO:1990404

HMNXSV003004462

HMNXSV003048767

Hs.50861.1.S1_3p_a_at

ILMN_1657868

TC12000942.hg

Participates

as a component of

SIRT4:Zn2+ [mitochondrial matrix] (Homo sapiens)

Inferred To

sir-2.2 [mitochondrial matrix] (Caenorhabditis elegans)

SIRT4 [mitochondrial matrix] (Bos taurus)

SIRT4 [mitochondrial matrix] (Canis familiaris)

SIRT4 [mitochondrial matrix] (Gallus gallus)

SIRT4 [mitochondrial matrix] (Rattus norvegicus)

SIRT4 [mitochondrial matrix] (Sus scrofa)

Sirt4 [mitochondrial matrix] (Drosophila melanogaster)

Sirt4 [mitochondrial matrix] (Mus musculus)

sirt4 [mitochondrial matrix] (Danio rerio)

sirt4 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_001372662.1, XP_006719372.1, XP_054227554.1, NP_036372.1, XP_006719371.1

Guide to Pharmacology - Targets

2710

ENSEMBL

ENSP00000202967, ENST00000202967, ENSG00000089163

OpenTargets

ENSG00000089163

GeneCards

SIRT4

HPA

ENSG00000089163-SIRT4

PRO

Q9Y6E7

Pharos - Targets

Q9Y6E7

HMDB Protein

HMDBP08882

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989)	0.643	3
UniProt:P10515 DLAT	4	Lipo-K259-DLAT [mitochondrial matrix] (R-HSA-69969) AcetyllipoH2-K132,K259-DLAT [mitochondrial matrix] (R-HSA-9861594) LipoH2-K259-DLAT [mitochondrial matrix] (R-HSA-9861664) DLAT [mitochondrial matrix] (R-HSA-6792585)	0.61	6
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2

Cite Us!