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SIRT5 [mitochondrial matrix]
Stable Identifier
R-HSA-5687778
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
fullName evidence="5"NAD-dependent protein deacylase sirtuin-5, mitochondrial ecNumber evidence="5"3.5.1.-/ecNumber, SIR5_HUMAN
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
SIRT5 deacetylates Cytochrome C (Homo sapiens)
SIRT5 [mitochondrial matrix] (Homo sapiens)
SIRT5:Zn2+ [mitochondrial intermembrane space] (Homo sapiens)
SIRT5 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NXA8 SIRT5
Gene Names
SIRT5, SIR2L5
Chain
transit peptide:1-36, chain:37-310
Reference Genes
BioGPS Gene:23408 SIRT5
COSMIC (genes):SIRT5 SIRT5
CTD Gene:23408 SIRT5
dbSNP Gene:23408 SIRT5
ENSEMBL:ENSG00000124523 SIRT5
ENSEMBL_homo_sapiens_GENE:ENSG00000124523.17 SIRT5
HGNC:14933 SIRT5
KEGG Gene (Homo sapiens):23408 SIRT5
Monarch:23408 SIRT5
NCBI Gene:23408 SIRT5
OMIM:604483 SIRT5
UCSC:Q9NXA8 SIRT5
Reference Transcript
RefSeq:NM_031244.3 SIRT5
RefSeq:NM_001193267.2 SIRT5
RefSeq:XM_005248968.4 SIRT5
RefSeq:NM_001242827.1 SIRT5
RefSeq:NM_012241.4 SIRT5
Other Identifiers
11728807_at
11729247_at
11749229_a_at
17004958
17004974
219185_PM_at
219185_at
221010_PM_s_at
221010_s_at
229112_PM_at
229112_at
23408
2895669
2895670
2895671
2895675
2895677
2895678
2895680
2895681
2895685
2895689
2895692
2895694
2895698
2895701
2895702
2895707
2895708
2895709
2895710
2895711
2895712
2895714
2895715
2895716
2895717
2895718
2895720
2895722
2895723
2895724
2895725
2895726
2895727
2895728
2895729
2895730
2895731
2895732
43640_at
47150_r_at
50108_at
62982_at
62983_g_at
8116956
A_23_P214812
A_32_P151366
A_33_P3271755
A_33_P3764802
GE55455
GE635713
GE80160
GO:0003824
GO:0005634
GO:0005737
GO:0005739
GO:0005758
GO:0005759
GO:0005829
GO:0006476
GO:0007005
GO:0008270
GO:0010566
GO:0010667
GO:0012501
GO:0016740
GO:0016787
GO:0031667
GO:0034979
GO:0036046
GO:0036047
GO:0036048
GO:0036049
GO:0036054
GO:0036055
GO:0036211
GO:0043226
GO:0046872
GO:0061697
GO:0061698
GO:0070403
GO:0140096
GO:2000378
HMNXSV003039842
HMNXSV003058223
Hs.26847.0.A1_3p_at
ILMN_1683059
ILMN_1738983
ILMN_1799598
ILMN_2291644
PH_hs_0023446
TC06000093.hg
TC06000094.hg
g13787213_3p_at
g13787214_3p_s_at
Participates
as a component of
SIRT5:Zn2+ [mitochondrial intermembrane space] (Homo sapiens)
Inferred To
SIRT5 [mitochondrial matrix]
(Bos taurus)
SIRT5 [mitochondrial matrix]
(Danio rerio)
SIRT5 [mitochondrial matrix]
(Dictyostelium discoideum)
SIRT5 [mitochondrial matrix]
(Gallus gallus)
SIRT5 [mitochondrial matrix]
(Mus musculus)
SIRT5 [mitochondrial matrix]
(Plasmodium falciparum)
SIRT5 [mitochondrial matrix]
(Rattus norvegicus)
SIRT5 [mitochondrial matrix]
(Sus scrofa)
SIRT5 [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005249025.1
,
NP_036373.1
,
NP_001180196.1
,
NP_001229756.1
,
NP_112534.1
Guide to Pharmacology - Targets
2711
OpenTargets
ENSG00000124523
HPA
ENSG00000124523-SIRT5
GeneCards
Q9NXA8
ZINC target
Q9NXA8
Ensembl
ENSG00000124523
,
ENST00000606117
,
ENST00000680707
,
ENST00000680432
,
ENSP00000505496
,
ENST00000680151
,
ENSP00000505469
,
ENSP00000368564
,
ENSP00000476228
,
ENSP00000505086
,
ENSP00000380509
,
ENSP00000352830
,
ENST00000359782
,
ENST00000379262
,
ENST00000397350
PRO
Q9NXA8
Pharos - Targets
Q9NXA8
HMDB Protein
HMDBP08883
PDB
6ACL
,
2NYR
,
4F56
,
5BWL
,
6LJK
,
4HDA
,
6LJM
,
7X3P
,
6EQS
,
5XHS
,
3RIY
,
6LJN
,
6ACO
,
2B4Y
,
4G1C
,
6ACE
,
3RIG
,
6ACP
,
4F4U
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