Reactome | PRPF18 [nucleoplasm]

PRPF18 [nucleoplasm]

Stable Identifier

R-HSA-5688093

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA-splicing factor 18, PRP18_HUMAN, hPrp18

Locations in the PathwayBrowser for interactor UniProt:Q4V328 GRAP1

Expand all

External Reference Information

External Reference

UniProt:Q99633 PRPF18

Gene Names

PRPF18, HPRP18

Chain

chain:1-342

Reference Genes

BioGPS Gene:8559 PRPF18

COSMIC (genes):PRPF18 PRPF18

CTD Gene:8559 PRPF18

dbSNP Gene:8559 PRPF18

ENSEMBL:ENSG00000165630 PRPF18

HGNC:17351 PRPF18

KEGG:hsa:8559 PRPF18

Monarch:8559 PRPF18

NCBI Gene:8559 PRPF18

OMIM:604993 PRPF18

UCSC:Q99633 PRPF18

Reference Transcript

RefSeq:NM_003675.3 PRPF18

Other Identifiers

11731492_at

16702608

221547_PM_at

221547_at

223685_PM_s_at

223685_s_at

2771401

3235937

3235938

3235939

3235944

3235946

3235949

3235952

3235954

3235955

3235956

3235957

3235958

3235959

3235960

3235965

3235966

3235967

3235968

3235969

3235970

3235971

3235974

3235975

3235982

3235983

3235984

3235985

3235986

3235987

3235988

3235989

3235990

3235991

3235992

3235993

3235994

3235997

3236000

3236010

3236012

3236014

40269_at

51840_at

7926283

8559

A_14_P120666

A_14_P128466

A_23_P127195

A_23_P418046

GE56701

GE62150

GO:0000350

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005682

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0043226

GO:0046540

GO:0065003

GO:0071021

HMNXSV003005161

HMNXSV003010915

HMNXSV003017933

HMNXSV003031061

HMNXSV003031370

ILMN_1807243

PH_hs_0023651

U51990_at

g12653992_3p_at

g12803490_3p_s_at

p25742

Participates

as an input of

Formation of the Spliceosomal C* complex (Homo sapiens)

as an output of

Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)

as a component of

Spliceosomal C* complex [nucleoplasm] (Homo sapiens)

Inferred To

PRPF18 [nucleoplasm] (Bos taurus)

PRPF18 [nucleoplasm] (Canis familiaris)

PRPF18 [nucleoplasm] (Gallus gallus)

PRPF18 [nucleoplasm] (Plasmodium falciparum)

PRPF18 [nucleoplasm] (Sus scrofa)

prp-18 [nucleoplasm] (Caenorhabditis elegans)

Prpf18 [nucleoplasm] (Mus musculus)

Prpf18 [nucleoplasm] (Rattus norvegicus)

prp18 [nucleoplasm] (Dictyostelium discoideum)

prp18 [nucleoplasm] (Schizosaccharomyces pombe)

prpf18 [nucleoplasm] (Danio rerio)

prpf18 [nucleoplasm] (Xenopus tropicalis)

Prp18 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_003666.1

OpenTargets

ENSG00000165630

ENSEMBL

ENST00000378572, ENSP00000367835

HPA

ENSG00000165630-PRPF18

PRO

Q99633

Pharos - Targets

Q99633

PDB

2DK4

Interactors (89)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6NT76 HMBX1			0.556	3
UniProt:P0DPB3-4 SCHIP1			0.556	3
UniProt:Q8NCX0-3 CCDC150			0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.556	3
UniProt:Q99598 TSNAX	1	TSNAX [cytosol] (R-HSA-5216130)	0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	5
UniProt:Q9H1I8 ASCC2	1	ASCC2 [nucleoplasm] (R-HSA-5656395)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q96MP8-2 KCTD7			0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.556	3
UniProt:O76083-2 PDE9A			0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q9UHV2 SRTD1			0.556	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q96IK5 GMCL1			0.556	3
UniProt:Q58EX7 PLEKHG4	1	PLEKHG4 [cytosol] (R-HSA-9679579)	0.556	3
UniProt:Q96S65 CSRN1			0.556	3
UniProt:Q68D86 C102B			0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
UniProt:Q86WP2 GPBP1			0.556	3
UniProt:Q9H4L5 OSBPL3	1	OSBPL3 [cytosol] (R-HSA-8867532)	0.556	3
UniProt:Q96RE7 NACC1			0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q5T124-6 UBXN11			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q4V328 GRAP1			0.556	3
UniProt:Q6PKC3 TXD11			0.556	3
UniProt:Q2TAA8 TXIP1			0.556	3
UniProt:O75031 HSF2B			0.556	3
IntAct:EBI-22314709 CCSB ORF ID			0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P23508 CRCM			0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:B7ZLH0 B7ZLH0			0.556	3
UniProt:O43447 PPIH	2	PPIH [nucleoplasm] (R-HSA-6806776) PPIH [cytosol] (R-HSA-9728791)	0.556	7
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q96CN4 EVI5L			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q6A163 KRT39	1	KRT39 [cytosol] (R-HSA-6809592)	0.556	3
UniProt:Q8TD16-2 BICD2			0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:O95994 AGR2			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q86UX7-2 FERMT3			0.556	3
UniProt:O95751 LDOC1			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:Q8TF50 ZN526			0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
IntAct:EBI-22402859 CCSB ORF ID			0.556	3
UniProt:A2RRN7 A2RRN7			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.556	3
UniProt:Q01850 CDR2			0.556	3
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:Q2TAC2-2 CCDC57			0.556	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.556	3
UniProt:Q9UID6 ZN639			0.556	5
UniProt:O75558 STX11			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3

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