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PRPF18 [nucleoplasm]
Stable Identifier
R-HSA-5688093
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Pre-mRNA-splicing factor 18, PRP18_HUMAN, hPrp18
Locations in the PathwayBrowser for interactor UniProt:Q9BWT7 CAR10
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
PRPF18 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
PRPF18 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99633 PRPF18
Gene Names
PRPF18, HPRP18
Chain
chain:1-342
Reference Genes
BioGPS Gene:8559 PRPF18
COSMIC (genes):PRPF18 PRPF18
CTD Gene:8559 PRPF18
dbSNP Gene:8559 PRPF18
ENSEMBL:ENSG00000165630 PRPF18
ENSEMBL_homo_sapiens_GENE:ENSG00000165630.15 PRPF18
HGNC:17351 PRPF18
KEGG Gene (Homo sapiens):8559 PRPF18
Monarch:8559 PRPF18
NCBI Gene:8559 PRPF18
OMIM:604993 PRPF18
UCSC:Q99633 PRPF18
Reference Transcript
RefSeq:NM_003675.3 PRPF18
Other Identifiers
11731492_at
16702608
221547_PM_at
221547_at
3235937
3235938
3235939
3235946
3235949
3235952
3235954
3235955
3235956
3235957
3235958
3235959
3235960
3235965
3235966
3235967
3235968
3235969
40269_at
7926283
8559
A_14_P128466
A_23_P127195
GE62150
GO:0000350
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0005682
GO:0006397
GO:0008380
GO:0016071
GO:0016607
GO:0043226
GO:0046540
GO:0065003
GO:0071021
HMNXSV003017933
ILMN_1807243
PH_hs_0023651
U51990_at
g12653992_3p_at
Participates
as an input of
Formation of the Spliceosomal C* complex (Homo sapiens)
as an output of
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
as a component of
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Inferred To
PRPF18 [nucleoplasm]
(Bos taurus)
PRPF18 [nucleoplasm]
(Canis familiaris)
PRPF18 [nucleoplasm]
(Gallus gallus)
PRPF18 [nucleoplasm]
(Plasmodium falciparum)
PRPF18 [nucleoplasm]
(Sus scrofa)
prp-18 [nucleoplasm]
(Caenorhabditis elegans)
Prpf18 [nucleoplasm]
(Mus musculus)
Prpf18 [nucleoplasm]
(Rattus norvegicus)
prp18 [nucleoplasm]
(Dictyostelium discoideum)
prp18 [nucleoplasm]
(Schizosaccharomyces pombe)
prpf18 [nucleoplasm]
(Danio rerio)
prpf18 [nucleoplasm]
(Xenopus tropicalis)
Prp18 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003666.1
OpenTargets
ENSG00000165630
HPA
ENSG00000165630-PRPF18
GeneCards
Q99633
Ensembl
ENSP00000367835
,
ENSG00000165630
,
ENST00000378572
PRO
Q99633
Pharos - Targets
Q99633
PDB
2DK4
Interactors (89)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6NT76 HMBX1
0.556
3
UniProt:P0DPB3-4 SCHIP1
0.556
3
UniProt:Q8NCX0-3 CCDC150
0.556
3
UniProt:Q9Y250 LZTS1
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q92764 KRT35
1
KRT35 [cytosol]
(R-HSA-6809595)
0.556
3
UniProt:P31321 PRKAR1B
2
PRKAR1B [cytosol]
(R-HSA-57838)
PRKAR1B [ciliary base]
(R-HSA-5610409)
0.556
3
UniProt:Q99598 TSNAX
1
TSNAX [cytosol]
(R-HSA-5216130)
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:P51114-2 FXR1
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.556
3
UniProt:Q99471 PFDN5
1
PFDN5 [cytosol]
(R-HSA-379548)
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.556
5
UniProt:Q9H1I8 ASCC2
1
ASCC2 [nucleoplasm]
(R-HSA-5656395)
0.556
3
UniProt:Q96MP8-2 KCTD7
0.556
3
UniProt:Q9H257-2 CARD9
0.556
3
UniProt:Q8ND90 PNMA1
0.556
3
UniProt:Q13137 CACO2
0.556
3
UniProt:O76083-2 PDE9A
0.556
3
UniProt:Q4G0R1 Q4G0R1
0.556
3
UniProt:Q9UHV2 SRTD1
0.556
3
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:Q96IK5 GMCL1
0.556
3
UniProt:Q58EX7 PLEKHG4
1
PLEKHG4 [cytosol]
(R-HSA-9679579)
0.556
3
UniProt:Q96S65 CSRN1
0.556
3
UniProt:Q68D86 C102B
0.556
3
UniProt:Q9Y2J4 AMOTL2
1
AMOTL2 [cytosol]
(R-HSA-2028606)
0.556
3
UniProt:Q86WP2 GPBP1
0.556
3
UniProt:Q9H4L5 OSBPL3
1
OSBPL3 [cytosol]
(R-HSA-8867532)
0.556
3
UniProt:Q96RE7 NACC1
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:Q5T124-6 UBXN11
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q4V328 GRAP1
0.556
3
UniProt:Q6PKC3 TXD11
0.556
3
UniProt:Q2TAA8 TXIP1
0.556
3
UniProt:O75031 HSF2B
0.556
3
IntAct:EBI-22314709 CCSB ORF ID
0.556
3
UniProt:Q7Z6G3-2 NECAB2
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:Q9UID6 ZN639
0.556
5
UniProt:Q2TAC2-2 CCDC57
0.556
3
UniProt:Q8NA61-2 CBY2
0.556
3
UniProt:Q01850 CDR2
0.556
3
UniProt:Q9BWT7 CAR10
0.556
3
UniProt:A2RRN7 A2RRN7
0.556
3
IntAct:EBI-22402859 CCSB ORF ID
0.556
3
UniProt:A1L4K1 FSD2
0.556
3
UniProt:Q8TF50 ZN526
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q6RW13-2 AGTRAP
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q63ZY3 KANK2
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:O95751 LDOC1
0.556
3
UniProt:Q86UX7-2 FERMT3
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q5W5X9-3 TTC23
0.556
3
IntAct:EBI-16435328 CCSB ORF ID
0.556
3
UniProt:O95994 AGR2
0.556
3
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q9BUH8 BEGAIN
1
BEGAIN [cytosol]
(R-HSA-6794250)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
UniProt:P23508 CRCM
0.556
3
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.556
3
UniProt:B7ZLH0 B7ZLH0
0.556
3
UniProt:O43447 PPIH
2
PPIH [nucleoplasm]
(R-HSA-6806776)
PPIH [cytosol]
(R-HSA-9728791)
0.556
7
UniProt:Q13422-7 IKZF1
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q96CN4 EVI5L
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q6A163 KRT39
1
KRT39 [cytosol]
(R-HSA-6809592)
0.556
3
UniProt:Q8TD16-2 BICD2
0.556
3
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