Reactome | TFG [cytosol]

TFG [cytosol]

Stable Identifier

R-HSA-5688159

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)
        
        TFG hexamer [cytosol] (Homo sapiens)
        
        TFG [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92734 TFG

Gene Names

TFG

Chain

chain:1-400

Reference Genes

BioGPS Gene:10342 TFG

COSMIC (genes):TFG TFG

CTD Gene:10342 TFG

dbSNP Gene:10342 TFG

ENSEMBL:ENSG00000114354 TFG

ENSEMBL_homo_sapiens_GENE:ENSG00000114354.15 TFG

HGNC:11758 TFG

KEGG Gene (Homo sapiens):10342 TFG

Monarch:10342 TFG

NCBI Gene:10342 TFG

OMIM:602498 TFG

UCSC:Q92734 TFG

Reference Transcript

Other Identifiers

10342

11715598_at

16943375

217839_PM_at

217839_at

2633774

2633775

2633776

2633777

2633779

2633780

2633781

2633782

2633784

2633787

2633789

2633791

2633798

2633802

2633805

2633806

2633807

2633809

8081316

88110_at

A_14_P136435

A_23_P29517

A_24_P345822

GE61614

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0006888

GO:0016192

GO:0023052

GO:0042802

GO:0043123

GO:0043226

GO:0043231

GO:0048208

GO:0061024

GO:0065003

GO:0070971

HMNXSV003004113

HMNXSV003056027

ILMN_1779213

ILMN_1812474

ILMN_2341815

PH_hs_0026111

TC03000512.hg

g5174718_3p_at

Participates

as a component of

TFG hexamer [cytosol] (Homo sapiens)

Other forms of this molecule

TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol]

TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol]

TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol]

TFG(1-193)-ALK(1058-1620) fusion [cytosol]

TFG(1-138)-ALK(1058-1620) fusion [cytosol]

TFG(1-240)-ALK(1058-1620) fusion [cytosol]

Inferred To

Ghost homologue of TFG [cytosol] (Dictyostelium discoideum)

Ghost homologue of TFG [cytosol] (Drosophila melanogaster)

Ghost homologue of TFG [cytosol] (Plasmodium falciparum)

Ghost homologue of TFG [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of TFG [cytosol] (Schizosaccharomyces pombe)

TFG [cytosol] (Bos taurus)

TFG [cytosol] (Canis familiaris)

TFG [cytosol] (Gallus gallus)

TFG [cytosol] (Sus scrofa)

Tfg [cytosol] (Mus musculus)

Tfg [cytosol] (Rattus norvegicus)

tfg [cytosol] (Xenopus tropicalis)

tfg-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016861017.1, XP_016861019.1, NP_001007566.1, XP_011510636.1, NP_001182408.1, XP_006713536.1, NP_001182407.1, XP_006713535.1, XP_016861018.1, XP_016861016.1, NP_006061.2, XP_005247123.1

OpenTargets

ENSG00000114354

GeneCards

Q92734

HPA

ENSG00000114354-TFG

Ensembl

ENSP00000420797, ENST00000675586, ENST00000675420, ENSP00000501892, ENST00000675553, ENST00000476228, ENSP00000502697, ENST00000675543, ENSP00000479269, ENSP00000502450, ENSG00000114354, ENST00000676111, ENST00000675243, ENSP00000479981, ENST00000676431, ENST00000487505, ENST00000675047, ENSP00000502497, ENSP00000419960, ENSP00000419504, ENST00000676395, ENSP00000502592, ENSP00000502071, ENSP00000240851, ENST00000620299, ENSP00000417952, ENST00000490574, ENST00000615993, ENSP00000501815, ENST00000674758, ENSP00000502516, ENST00000240851, ENSP00000502502, ENST00000676308, ENSP00000502229, ENSP00000502329, ENST00000674615, ENSP00000502698, ENST00000675499, ENST00000674645, ENST00000463568, ENSP00000502734, ENSP00000502139

PRO

Q92734

Pharos - Targets

Q92734

Orphanet

15604

PDB

8TEQ, 8TER

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.718	8
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.707	7
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994)	0.527	2
UniProt:O94979 SEC31A	5	SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713475) SEC31A(1-989)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713478) SEC31A [ER to Golgi transport vesicle membrane] (R-HSA-204010) SEC31A [endoplasmic reticulum membrane] (R-HSA-204000) SEC31A [cytosol] (R-HSA-203983)	0.527	2

Cite Us!