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SEC22A [ER to Golgi transport vesicle membrane]
Stable Identifier
R-HSA-5688560
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ER to Golgi transport vesicle membrane
Synonyms
Vesicle-trafficking protein SEC22a, SC22A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
SEC22A [ER to Golgi transport vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96IW7 SEC22A
Gene Names
SEC22A, SEC22L2
Chain
initiator methionine:, chain:2-307
Reference Genes
BioGPS Gene:26984 SEC22A
COSMIC (genes):SEC22A SEC22A
CTD Gene:26984 SEC22A
dbSNP Gene:26984 SEC22A
ENSEMBL:ENSG00000121542 SEC22A
HGNC:20260 SEC22A
KEGG:hsa:26984 SEC22A
Monarch:26984 SEC22A
NCBI Gene:26984 SEC22A
OMIM:612442 SEC22A
UCSC:Q96IW7 SEC22A
Reference Transcript
RefSeq:XM_011512676.2 SEC22A
RefSeq:XM_011512675.2 SEC22A
RefSeq:NM_012430.4 SEC22A
RefSeq:XM_011512673.2 SEC22A
Other Identifiers
11720987_at
11720988_at
16944763
218703_PM_at
218703_at
238078_PM_at
238078_at
2639310
2639311
2639312
2639314
2639317
2639318
2639325
2639326
2639327
2639328
2639329
2639330
2639340
2639341
2639342
2639343
2639348
2639352
2639353
2639354
2639355
2639356
2639357
2639358
2639359
2639360
2639362
26984
46901_at
48596_at
8082153
A_14_P117180
A_23_P259874
A_32_P233019
GE79743
GO:0005484
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0006888
GO:0006890
GO:0015031
GO:0016020
GO:0016192
GO:0031410
GO:0033116
GO:0042470
GO:0043226
GO:0043231
GO:0060090
GO:0061024
GO:0061025
HMNXSV003014068
Hs.53126.0.A1_3p_at
ILMN_1775036
PH_hs_0025151
TC03003364.hg
g6912647_3p_at
Participates
as a candidate of
ER-to-ERGIC v-SNARES [ER to Golgi transport vesicle membrane] (Homo sapiens)
Other forms of this molecule
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
SEC22A [endoplasmic reticulum membrane]
Inferred To
Sec22a [ER to Golgi transport vesicle membrane]
(Mus musculus)
Sec22a [ER to Golgi transport vesicle membrane]
(Rattus norvegicus)
SEC22A [ER to Golgi transport vesicle membrane]
(Bos taurus)
SEC22A [ER to Golgi transport vesicle membrane]
(Canis familiaris)
SEC22A [ER to Golgi transport vesicle membrane]
(Gallus gallus)
SEC22A [ER to Golgi transport vesicle membrane]
(Sus scrofa)
sec22a [ER to Golgi transport vesicle membrane]
(Danio rerio)
sec22a [ER to Golgi transport vesicle membrane]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000121542
ENSEMBL
ENST00000492595
,
ENST00000309934
,
ENSP00000310521
,
ENSP00000417972
HPA
ENSG00000121542-SEC22A
PRO
Q96IW7
Pharos - Targets
Q96IW7
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92838 EDA
1
EDA [plasma membrane]
(R-HSA-5667156)
0.781
7
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.718
6
UniProt:P11686 SFTPC
9
pro-SFTPC P115L [endoplasmic reticulum membrane]
(R-HSA-5688352)
pro-SFTPC P30L [endoplasmic reticulum membrane]
(R-HSA-5688365)
pro-SFTPC [endoplasmic reticulum membrane]
(R-HSA-5683842)
pro-SFTPC [multivesicular body lumen]
(R-HSA-5685298)
SFTPC [extracellular region]
(R-HSA-5683685)
SFTPC [clathrin-coated endocytic vesicle]
(R-HSA-5686342)
SFTPC [lamellar body]
(R-HSA-5683717)
SFTPC(24-58) [multivesicular body lumen]
(R-HSA-5685899)
SFTPC(59-197) [multivesicular body lumen]
(R-HSA-5685871)
0.718
6
UniProt:Q05329 GAD2
2
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888582)
PXLP-K396-GAD2 [plasma membrane]
(R-HSA-936509)
0.556
3
UniProt:Q9NR28 DIABLO
2
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
DIABLO [cytosol]
(R-HSA-114298)
0.556
3
UniProt:Q96A56 TP53INP1
1
TP53INP1 [nucleoplasm]
(R-HSA-3215226)
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q9NX18 SDHAF2
1
SDHAF2 [mitochondrial matrix]
(R-HSA-9854689)
0.556
3
UniProt:P32942 ICAM3
1
ICAM3 [plasma membrane]
(R-HSA-197682)
0.556
3
UniProt:P35232 PHB
2
PHB [cytosol]
(R-HSA-5672944)
PHB [mitochondrial inner membrane]
(R-HSA-8953720)
0.556
3
UniProt:O60883 GPR37L1
1
GPR37L1 [plasma membrane]
(R-HSA-5336178)
0.556
3
UniProt:P21217 FUT3
1
FUT3 [Golgi membrane]
(R-HSA-5693934)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:P43657 LPAR6
1
LPAR6 [plasma membrane]
(R-HSA-417913)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:P50876 RNF144A
1
RNF144A [endosome membrane]
(R-HSA-8938771)
0.556
3
UniProt:Q8IUN9 CLEC10A
1
CLEC10A [plasma membrane]
(R-HSA-1472863)
0.556
3
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.556
3
UniProt:Q9BRI3 SLC30A2
2
SLC30A2 [endosome membrane]
(R-HSA-435363)
SLC30A2 [synaptic vesicle membrane]
(R-HSA-4084714)
0.556
3
UniProt:P63252 KCNJ2
1
KCNJ2 [plasma membrane]
(R-HSA-975378)
0.556
3
UniProt:Q6PIZ9 TRAT1
1
p-Y63,Y79,Y110-TRAT1 [plasma membrane]
(R-HSA-202201)
0.556
3
UniProt:P17643 TYRP1
1
TYRP1 [melanosome membrane]
(R-HSA-8878574)
0.556
3
UniProt:Q9GZU1 MCOLN1
2
MCOLN1 [plasma membrane]
(R-HSA-3211764)
MCOLN1 [endosome membrane]
(R-HSA-917803)
0.556
3
UniProt:Q9UP52 TFR2
1
TFR2 [plasma membrane]
(R-HSA-5691118)
0.556
3
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