Reactome | CHD1L [nucleoplasm]

CHD1L [nucleoplasm]

Stable Identifier

R-HSA-5688916

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromodomain-helicase-DNA-binding protein 1-like, ALC1, Amplified in liver cancer protein 1

Locations in the PathwayBrowser for interactor UniProt:P31749 AKT1

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External Reference Information

External Reference

UniProt:Q86WJ1 CHD1L

Gene Names

CHD1L, ALC1

Chain

chain:1-897

Reference Genes

BioGPS Gene:9557 CHD1L

COSMIC (genes):CHD1L CHD1L

CTD Gene:9557 CHD1L

dbSNP Gene:9557 CHD1L

ENSEMBL:ENSG00000131778 CHD1L

HGNC:1916 CHD1L

KEGG:hsa:9557 CHD1L

Monarch:9557 CHD1L

NCBI Gene:9557 CHD1L

OMIM:613039 CHD1L

UCSC:Q86WJ1 CHD1L

Reference Transcript

Participates

as an output of

3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)

as an input of

CHD1L is recruited to GG-NER site (Homo sapiens)

as a component of

Inferred To

Chd1l [nucleoplasm] (Mus musculus)

Chd1l [nucleoplasm] (Rattus norvegicus)

Ghost homologue of CHD1L [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of CHD1L [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of CHD1L [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of CHD1L [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of CHD1L [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of CHD1L [nucleoplasm] (Xenopus tropicalis)

chd1l [nucleoplasm] (Danio rerio)

CHD1L [nucleoplasm] (Bos taurus)

CHD1L [nucleoplasm] (Canis familiaris)

CHD1L [nucleoplasm] (Gallus gallus)

CHD1L [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001335391.1, NP_001335390.1, NP_004275.4, NP_001243266.1, NP_001243267.1, NP_001335395.1, NP_001335394.1, NP_078844.2, NP_001335385.1, NP_001335389.1, NP_001335386.1, NP_001335388.1, NP_001335387.1, NP_001335382.1, NP_001335392.1, NP_001335393.1

OpenTargets

ENSG00000131778

ENSEMBL

ENST00000369259, ENST00000369258, ENSG00000131778, ENSP00000358263, ENSP00000358262

HPA

ENSG00000131778-CHD1L

GeneCards

CHD1L

PRO

Q86WJ1

Pharos - Targets

Q86WJ1

GlyGen

Q86WJ1

PDB

7ENN, 6ZHY, 6ZHX, 8B0A, 7OTQ, 7EPU

HMDB Protein

HMDBP11637

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.643	4
UniProt:Q13304 GPR17	1	GPR17 [plasma membrane] (R-HSA-416429)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q8IW19 APLF			0.527	2
UniProt:O95271 TNKS	1	TNKS [cytosol] (R-HSA-3640825)	0.527	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2

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