Reactome | LTN1 [cytosol]

LTN1 [cytosol]

Stable Identifier

R-HSA-5688967

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase listerin ecNumber6.3.2.-/ecNumber, LTN1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9UQV4 LAMP3

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External Reference Information

External Reference

UniProt:O94822 LTN1

Gene Names

LTN1, C21orf10, C21orf98, KIAA0714, RNF160, ZNF294, HSPC087

Chain

chain:1-1766

Reference Genes

BioGPS Gene:26046 LTN1

COSMIC (genes):LTN1 LTN1

CTD Gene:26046 LTN1

dbSNP Gene:26046 LTN1

ENSEMBL:ENSG00000198862 LTN1

HGNC:13082 LTN1

KEGG:hsa:26046 LTN1

Monarch:26046 LTN1

NCBI Gene:26046 LTN1

OMIM:613083 LTN1

UCSC:O94822 LTN1

Reference Transcript

Other Identifiers

11724925_at

11724926_at

16924668

215596_PM_s_at

215596_s_at

233818_PM_at

233818_at

233819_PM_s_at

233819_s_at

26046

39005_s_at

3927956

3927957

3927958

3927959

3927960

3927961

3927962

3927963

3927964

3927966

3927967

3927968

3927973

3927974

3927975

3927977

3927978

3927979

3927980

3927981

3927982

3927984

3927985

3927986

3927987

3927988

3927989

3927990

3927991

3927992

3927993

3927994

3927995

3927996

3927997

3927999

3928000

3928001

3928002

3928003

3928004

3928005

3928006

3928008

3928009

3928010

3928011

3928012

3928013

3928014

3928015

3928019

3928020

3928021

8069711

A_32_P115505

A_33_P3304865

GE53438

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005829

GO:0005840

GO:0008270

GO:0016567

GO:0016740

GO:0022626

GO:0030163

GO:0043023

GO:0043161

GO:0046872

GO:0051865

GO:0061630

GO:0072344

GO:0140096

GO:1990112

GO:1990116

HMNXSV003000209

HMNXSV003043140

Hs.288773.1.S1_3p_a_at

Hs.288773.2.S1_3p_a_at

ILMN_1760360

ILMN_2077504

PH_hs_0014996

TC21000351.hg

Participates

as an output of

The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer (Homo sapiens)

as a component of

as an input of

LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of LTN1 [cytosol] (Plasmodium falciparum)

ltn1 [cytosol] (Danio rerio)

ltn1 [cytosol] (Xenopus tropicalis)

rkr1 [cytosol] (Schizosaccharomyces pombe)

RKR1 [cytosol] (Saccharomyces cerevisiae)

Ltn1 [cytosol] (Drosophila melanogaster)

Ltn1 [cytosol] (Mus musculus)

Ltn1 [cytosol] (Rattus norvegicus)

LTN1 [cytosol] (Bos taurus)

LTN1 [cytosol] (Caenorhabditis elegans)

LTN1 [cytosol] (Canis familiaris)

LTN1 [cytosol] (Gallus gallus)

LTN1 [cytosol] (Sus scrofa)

rnf160 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001307695.1, NP_056380.3

OpenTargets

ENSG00000198862

ENSEMBL

ENST00000361371, ENST00000707893, ENST00000389194, ENST00000707894, ENST00000707899, ENST00000614971, ENSG00000291534, ENSP00000478783, ENSP00000354977, ENSG00000198862, ENSP00000373846, ENSP00000517022, ENSP00000517021, ENSP00000517025

IntEnz

2.3.2.27

HPA

ENSG00000198862-LTN1

GeneCards

LTN1

PRO

O94822

Pharos - Targets

O94822

GlyGen

O94822

PDB

3J92

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:Q13304 GPR17	1	GPR17 [plasma membrane] (R-HSA-416429)	0.527	2
UniProt:P27361 MAPK3	6	p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295)	0.527	2
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.527	2
UniProt:P20309 CHRM3	1	CHRM3 [plasma membrane] (R-HSA-399994)	0.527	2
UniProt:Q9UQV4 LAMP3			0.527	2
UniProt:P01889 HLA-B	8	class I MHC B7 [lumenal side of endoplasmic reticulum membrane] (R-HSA-983073) class I MHC B7 [plasma membrane] (R-HSA-167756) class I MHC B7 [secretory granule membrane] (R-HSA-6804794) class I MHC B7 [Golgi membrane] (R-HSA-983379) class I MHC B7 [ER to Golgi transport vesicle membrane] (R-HSA-983362) class I MHC B7 [early endosome membrane] (R-HSA-1236872) class I MHC B7 [recycling endosome membrane] (R-HSA-8863942) class I MHC B7 [phagocytic vesicle membrane] (R-HSA-1236753)	0.527	3
UniProt:Q9ULX7 CA14	1	CA14 [plasma membrane] (R-HSA-1237018)	0.527	2
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:O43493 TGOLN2	8	TGOLN2 [endoplasmic reticulum lumen] (R-HSA-8956702) p-TGOLN2 [endoplasmic reticulum lumen] (R-HSA-8956886) TGOLN2 [plasma membrane] (R-HSA-8864458) TGOLN2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869127) TGOLN2 [transport vesicle] (R-HSA-6811011) TGOLN2 [trans-Golgi network membrane] (R-HSA-6811008) TGOLN2 [cytoplasmic vesicle membrane] (R-HSA-429818) TGOLN2 [Golgi membrane] (R-HSA-434342)	0.527	2
UniProt:P25942 CD40			0.527	2
UniProt:P49146 NPY2R	1	NPY2R [plasma membrane] (R-HSA-388905)	0.527	2
UniProt:Q8TBP5 F174A			0.527	2
UniProt:Q6EMK4 VASN			0.527	2
UniProt:O43825 B3GALT2	1	B3GALT2 [Golgi membrane] (R-HSA-913712)	0.527	2
UniProt:Q9UK85 DKKL1			0.527	2
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.527	2
UniProt:Q86WV6 STING1	7	STING [endoplasmic reticulum membrane] (R-HSA-1834940) TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) STING(1-95) [cytosol] (R-HSA-3244586) STING(96-379) [cytosol] (R-HSA-3244622)	0.499	2
UniProt:P58753 TIRAP	2	p-4Y-TIRAP [plasma membrane] (R-HSA-2201321) TIRAP [cytosol] (R-HSA-166141)	0.499	2
UniProt:Q92985 IRF7	5	IRF7 [cytosol] (R-HSA-450281) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) IRF7 [endosome membrane] (R-HSA-450274) K63polyUb-IRF7 [endosome membrane] (R-HSA-975154)	0.499	2

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