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SH3RF1 [cytosol]
Stable Identifier
R-HSA-5688968
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase SH3RF1 ecNumber6.3.2.-/ecNumber, SH3R1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOV GTPase cycle (Homo sapiens)
RHOV binds effectors at the plasma membrane (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
SH3RF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7Z6J0 SH3RF1
Gene Names
SH3RF1, KIAA1494, POSH, POSH1, RNF142, SH3MD2
Chain
chain:1-888
Reference Genes
BioGPS Gene:57630 SH3RF1
COSMIC (genes):SH3RF1 SH3RF1
CTD Gene:57630 SH3RF1
dbSNP Gene:57630 SH3RF1
ENSEMBL:ENSG00000154447 SH3RF1
HGNC:17650 SH3RF1
KEGG:hsa:57630 SH3RF1
Monarch:57630 SH3RF1
NCBI Gene:57630 SH3RF1
OMIM:618642 SH3RF1
UCSC:Q7Z6J0 SH3RF1
Reference Transcript
RefSeq:NM_020870.3 SH3RF1
Other Identifiers
11732258_s_at
11754273_a_at
11755948_a_at
16981345
225589_PM_at
225589_at
225590_PM_at
225590_at
2793147
2793148
2793149
2793150
2793151
2793152
2793154
2793155
2793156
2793158
2793159
2793160
2793161
2793165
2793167
2793171
2793172
2793186
2793187
2793188
2793189
2793190
2793191
43090_at
56001_at
56002_at
57630
61632_at
8103630
A_24_P100551
A_24_P418762
GE57024
GO:0000165
GO:0001764
GO:0003824
GO:0005078
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0016567
GO:0016740
GO:0030027
GO:0032436
GO:0042995
GO:0043066
GO:0043154
GO:0043226
GO:0043370
GO:0046330
GO:0046872
GO:0048471
GO:0048870
GO:0051865
GO:0060090
GO:0061630
GO:0140096
GO:1904044
GO:2000564
GO:2001237
HMNXSV003033225
Hs.301804.0.S1_3p_at
Hs.301804.0.S2_3p_at
ILMN_1656826
PH_hs_0032574
TC04001724.hg
TC04002813.hg
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
sh3rf1 [cytosol]
(Danio rerio)
sh3rf1 [cytosol]
(Xenopus tropicalis)
SH3RF1 [cytosol]
(Bos taurus)
SH3RF1 [cytosol]
(Canis familiaris)
SH3RF1 [cytosol]
(Dictyostelium discoideum)
SH3RF1 [cytosol]
(Gallus gallus)
SH3RF1 [cytosol]
(Sus scrofa)
POSH [cytosol]
(Drosophila melanogaster)
Sh3rf1 [cytosol]
(Mus musculus)
Sh3rf1 [cytosol]
(Rattus norvegicus)
Homologues of SH3RF1 [cytosol]
(Dictyostelium discoideum)
PIN3 [cytosol]
(Saccharomyces cerevisiae)
sfp47 [cytosol]
(Schizosaccharomyces pombe)
Cross References
ENSEMBL
ENST00000284637
,
ENSP00000284637
,
ENSG00000154447
OpenTargets
ENSG00000154447
GeneCards
SH3RF1
HPA
ENSG00000154447-SH3RF1
PRO
Q7Z6J0
Pharos - Targets
Q7Z6J0
GlyGen
Q7Z6J0
HMDB Protein
HMDBP08579
PDB
7NZC
,
7NZD
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43255 SIAH2
1
SIAH2 [cytosol]
(R-HSA-374566)
0.632
3
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
0.592
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.499
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.499
2
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