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SHPRH [nucleoplasm]
Stable Identifier
R-HSA-5689010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase SHPRH ecNumber3.6.4.-/ecNumber ecNumber6.3.2.-/ecNumber, SHPRH_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q8WWZ3 EDARADD
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
SHPRH [nucleoplasm] (Homo sapiens)
SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
SHPRH [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q149N8 SHPRH
Gene Names
SHPRH, KIAA2023
Chain
chain:1-1683
Reference Genes
COSMIC (genes):SHPRH SHPRH
dbSNP Gene:257218 SHPRH
ENSEMBL:ENSG00000146414 SHPRH
Participates
as an input of
SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
as an output of
SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
as a component of
SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)
Inferred To
Shprh [nucleoplasm]
(Rattus norvegicus)
shprh [nucleoplasm]
(Xenopus tropicalis)
SHPRH [nucleoplasm]
(Bos taurus)
SHPRH [nucleoplasm]
(Caenorhabditis elegans)
SHPRH [nucleoplasm]
(Canis familiaris)
SHPRH [nucleoplasm]
(Dictyostelium discoideum)
SHPRH [nucleoplasm]
(Gallus gallus)
SHPRH [nucleoplasm]
(Mus musculus)
SHPRH [nucleoplasm]
(Schizosaccharomyces pombe)
SHPRH [nucleoplasm]
(Sus scrofa)
Dmel\CG7376 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of SHPRH [nucleoplasm]
(Danio rerio)
Ghost homologue of SHPRH [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of SHPRH [nucleoplasm]
(Saccharomyces cerevisiae)
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.643
4
UniProt:Q96GS4 BORC6
0.556
3
UniProt:Q8WWZ3 EDARADD
1
EDARADD [cytosol]
(R-HSA-5675659)
0.556
3
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