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Ub-6-UBA52(1-76) [cytosol]
Stable Identifier
R-HSA-5689082
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
SIAH1, SIAH2 ubiquitinate SNCAIP (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Josephin domain DUBs (Homo sapiens)
ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
PARK2 autoubiquitinates (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP10 deubiquitinates SNX3, CFTR (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP11 deubiquitinates NFKBIA (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP25 deubiquitinates DDX58 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
USP5 cleaves polyubiquitin (Homo sapiens)
USP5:PolyUb [cytosol] (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
USP17L2 deubiquitinates RCE1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K6polyUb [cytosol] (Homo sapiens)
K6-Ub [cytosol] (Homo sapiens)
Ub-6-UBA52(1-76) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62987 UBA52
Gene Names
UBA52, UBCEP2
Chain
chain:1-76, chain:77-128
Reference Genes
BioGPS Gene:7311 UBA52
COSMIC (genes):UBA52 UBA52
CTD Gene:7311 UBA52
dbSNP Gene:7311 UBA52
ENSEMBL:ENSG00000221983 UBA52
HGNC:12458 UBA52
KEGG Gene (Homo sapiens):7311 UBA52
Monarch:7311 UBA52
NCBI Gene:7311 UBA52
OMIM:191321 UBA52
Reference Transcript
RefSeq:NM_003333.4 UBA52
RefSeq:NM_001033930.2 UBA52
RefSeq:NM_001321018.1 UBA52
RefSeq:NM_001321017.1 UBA52
RefSeq:NM_001321019.1 UBA52
RefSeq:NM_001321020.1 UBA52
Other Identifiers
0004920441
11729104_x_at
11756215_x_at
16859825
221700_s_at
3476750
3537801
3825202
3825203
3825204
3825206
3825207
3825208
3825209
3825210
3825212
3825214
3825216
3825217
3825218
3825219
3825220
3825221
3825222
3825224
58604_s_at
7311
8027024
A_23_P56188
A_23_P56195
A_24_P173325
A_24_P65779
GE79164
GE85590
GE85604
GO:0000122
GO:0000184
GO:0000187
GO:0000209
GO:0000278
GO:0000715
GO:0000717
GO:0002181
GO:0002753
GO:0002755
GO:0002756
GO:0003674
GO:0003735
GO:0005198
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005829
GO:0005840
GO:0005886
GO:0006259
GO:0006283
GO:0006294
GO:0006296
GO:0006297
GO:0006364
GO:0006412
GO:0006413
GO:0006464
GO:0006605
GO:0006614
GO:0006810
GO:0006914
GO:0006950
GO:0007049
GO:0007096
GO:0007165
GO:0007179
GO:0007249
GO:0007254
GO:0007267
GO:0008104
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0010008
GO:0015031
GO:0016055
GO:0016192
GO:0016197
GO:0016567
GO:0016579
GO:0017085
GO:0019058
GO:0019068
GO:0019081
GO:0019083
GO:0019221
GO:0019899
GO:0019941
GO:0019985
GO:0022607
GO:0022625
GO:0022626
GO:0022627
GO:0030512
GO:0030666
GO:0031145
GO:0031386
GO:0031410
GO:0031625
GO:0031982
GO:0032991
GO:0033683
GO:0034641
GO:0034655
GO:0035666
GO:0035973
GO:0036297
GO:0036388
GO:0042254
GO:0042276
GO:0042769
GO:0043065
GO:0043066
GO:0043226
GO:0043488
GO:0043657
GO:0044322
GO:0044403
GO:0045944
GO:0051092
GO:0051276
GO:0051403
GO:0052031
GO:0055085
GO:0061024
GO:0061418
GO:0065003
GO:0070062
GO:0070423
GO:0070498
GO:0070911
GO:0070987
GO:0075733
GO:0140014
GO:1904380
GO:1990000
HMNXSV003054363
ILMN_1782977
ILMN_2368576
PH_hs_0028727
PH_hs_0037046
TC19000360.hg
X56997_rna1_at
g13569611_3p_s_at
Participates
as a member of
K6-Ub [cytosol] (Homo sapiens)
Other forms of this molecule
UBA52(1-76) [endocytic vesicle membrane]
Ub-33-UBA52(1-76) [mitochondrial outer membrane]
Ub-63-UBA52(1-76) [mitochondrial outer membrane]
Ub-6-UBA52(1-76) [mitochondrial outer membrane]
Ub-11-UBA52(1-76) [mitochondrial outer membrane]
Ub-48-UBA52(1-76) [mitochondrial outer membrane]
Ub-29-UBA52(1-76) [mitochondrial outer membrane]
Ub-27-UBA52(1-76) [mitochondrial outer membrane]
N6-glycyl-L-lysine-UBA52(1-76) [cytosol]
adenylatedG76-UBA52(1-76) [nucleoplasm]
UBA52(1-128) [cytosol]
adenylatedG76-UBA52(1-76) [cytosol]
Ub-48-UBA52(1-76) [endoplasmic reticulum membrane]
Ub-48-UBA52(1-76) [lysosomal membrane]
Ub-48-UBA52(1-76) [endocytic vesicle membrane]
UBA52(1-76) [plasma membrane]
UBA52(1-76) [endosome membrane]
Ub-29-UBA52(1-76) [cytosol]
Ub-33-UBA52(1-76) [cytosol]
Ub-27-UBA52(1-76) [cytosol]
RPL40 [cytosol]
UBA52(1-76) [endoplasmic reticulum membrane]
Ub-27-UBA52(1-76) [nucleoplasm]
Ub-29-UBA52(1-76) [nucleoplasm]
Ub-33-UBA52(1-76) [nucleoplasm]
Ub-11-UBA52(1-76) [nucleoplasm]
Ub-63-UBA52(1-76) [endosome membrane]
Ub-63-UBA52(1-76) [plasma membrane]
Ub-11-UBA52(1-76) [cytosol]
Ub-48-UBA52(1-76) [nucleoplasm]
UBA52(1-76) [nucleoplasm]
Ub-63-UBA52(1-76) [nucleoplasm]
Ub-6-UBA52(1-76) [nucleoplasm]
UBA52(1-76) [late endosome lumen]
Ub-48-UBA52(1-76) [cytosol]
UBA52(1-76) [cytosol]
UBA52(1-76) [lysosomal lumen]
Ub-63-UBA52(1-76) [cytosol]
Inferred To
RPL40B [cytosol]
(Saccharomyces cerevisiae)
UBA52 [cytosol]
(Bos taurus)
UBA52 [cytosol]
(Canis familiaris)
UBA52 [cytosol]
(Sus scrofa)
RPS31 [cytosol]
(Saccharomyces cerevisiae)
Ub-6-UBA52(1-76) [cytosol]
(Xenopus tropicalis)
ubi3 [cytosol]
(Schizosaccharomyces pombe)
Uba52 [cytosol]
(Mus musculus)
Uba52 [cytosol]
(Rattus norvegicus)
nedd8l1 [cytosol]
(Dictyostelium discoideum)
ubq-1 [cytosol]
(Caenorhabditis elegans)
Homologues of Ub-6-RPS27A(1-76) [cytosol]
(Saccharomyces cerevisiae)
Homologues of Ub-6-RPS27A(1-76) [cytosol]
(Schizosaccharomyces pombe)
uep1 [cytosol]
(Schizosaccharomyces pombe)
ubi5 [cytosol]
(Schizosaccharomyces pombe)
uba52 [cytosol]
(Danio rerio)
RpL40 [cytosol]
(Drosophila melanogaster)
ubi1 [cytosol]
(Schizosaccharomyces pombe)
RPL40A [cytosol]
(Saccharomyces cerevisiae)
UBB [cytosol]
(Gallus gallus)
Modified Residues
Name
ubiquitinylated lysine at 6
Coordinate
6
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001307947.1
,
NP_001307946.1
,
NP_001307948.1
,
NP_003324.1
,
NP_001307949.1
,
NP_001029102.1
OpenTargets
ENSG00000221983
HPA
ENSG00000221983-UBA52
GeneCards
P62987
Ensembl
ENSP00000470507
,
ENSP00000470419
,
ENST00000442744
,
ENST00000599595
,
ENSP00000472545
,
ENSP00000471622
,
ENST00000595158
,
ENST00000598780
,
ENST00000430157
,
ENSG00000221983
,
ENST00000595683
,
ENSP00000388107
,
ENSP00000396910
,
ENSP00000473048
,
ENST00000599551
,
ENST00000597451
,
ENST00000596273
,
ENSP00000472264
,
ENST00000596304
,
ENSP00000471062
,
ENSP00000471464
PRO
P62987
Pharos - Targets
P62987
GlyGen
P62987
PDB
4P4H
,
5GOD
,
5GOC
,
5HPL
,
2MJB
,
5LKS
,
2RSU
,
5HPS
,
5GOG
,
4JIO
,
6Y0G
,
4S1Z
,
4PIG
,
5HPT
,
2MBH
,
4UG0
,
5GOH
,
4PIH
,
5GOI
,
4PIJ
,
2N3U
,
5GOJ
,
5GOK
,
2N3V
,
6Z6M
,
6Y57
,
6QZP
,
4HJK
,
2N3W
,
6Z6L
,
4RF0
,
4RF1
,
6Z6N
,
6IP5
,
5J8P
,
6IP6
,
6LQM
,
7BHP
,
6IP8
,
2LJ5
,
5AJ0
,
6XA1
,
7OWC
,
6OLE
,
6OLF
,
5J26
,
6ZM7
,
7AY1
,
6OLG
,
6Y2L
,
6OLI
,
2NBD
,
6OM0
,
2NBE
,
6Y6X
,
5GO7
,
6OM7
,
6ZMI
,
5JBV
,
7M3Q
,
2MUR
,
6ZME
,
4V6X
,
4XKL
,
5GO8
,
6OLZ
,
5JBY
,
5T2C
,
5GOB
,
6ZMO
,
5HPK
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y3C5 RNF11
0.666
4
UniProt:Q15038 DAZP2
0.666
7
UniProt:Q6ICB0 DESI1
0.601
4
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:O95208-2 EPN2
0.556
3
UniProt:Q9UJ41-4 RABGEF1
0.556
3
UniProt:Q99732 LITAF
0.556
3
UniProt:Q9NRQ2 PLS4
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:Q96CS7 PKHB2
0.556
3
UniProt:Q92567-2 FAM168A
0.556
3
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.556
3
UniProt:Q96B67 ARRD3
0.556
3
UniProt:Q14203-5 DCTN1
0.556
3
UniProt:P37840 SNCA
4
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.495
2
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