Reactome | polyUb-PARK2 [cytosol]

polyUb-PARK2 [cytosol]

Stable Identifier

R-HSA-5689094

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Parkin

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Locations in the PathwayBrowser for interactor UniProt:Q9BXM7 PINK1

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External Reference Information

External Reference

UniProt:O60260 PARK2

Gene Names

PARK2, PRKN

Chain

chain:1-465

Reference Genes

COSMIC (genes):PRKN PRKN

dbSNP Gene:5071 PRKN

ENSEMBL:ENSG00000185345 PARK2

Participates

as an input of

ATXN3 binds polyUb-PARK2 (Homo sapiens)

as a component of

ATXN3:polyUb-PARK2 [cytosol] (Homo sapiens)

as an output of

PARK2 autoubiquitinates (Homo sapiens)

Other forms of this molecule

p-S9-PRKN [cytosol]

p-S65-PRKN [cytosol]

PRKN [cytosol]

Inferred To

PRKN [cytosol] (Bos taurus)

PRKN [cytosol] (Canis familiaris)

polyUb-PARK2 [cytosol] (Dictyostelium discoideum)

polyUb-PARK2 [cytosol] (Drosophila melanogaster)

polyUb-PARK2 [cytosol] (Gallus gallus)

polyUb-PARK2 [cytosol] (Mus musculus)

polyUb-PARK2 [cytosol] (Plasmodium falciparum)

polyUb-PARK2 [cytosol] (Rattus norvegicus)

polyUb-PARK2 [cytosol] (Saccharomyces cerevisiae)

polyUb-PARK2 [cytosol] (Schizosaccharomyces pombe)

Homologues of polyUb-PARK2 [cytosol] (Dictyostelium discoideum)

prkn [cytosol] (Danio rerio)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXM7 PINK1	5	PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628) PINK1 [cytosol] (R-HSA-5205637) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051)	0.748	7
UniProt:Q15645 PCH2			0.712	4
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.639	11
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.623	10
IntAct:EBI-4399559 UBIQ			0.623	2
UniProt:O60260 PARK2	4	polyUb-PARK2 [cytosol] (R-HSA-5689094) p-S9-PRKN [cytosol] (R-HSA-9793481) p-S65-PRKN [cytosol] (R-HSA-9834954) PRKN [cytosol] (R-HSA-201579)	0.618	5
UniProt:P68510 Ywhah	1	14-3-3 eta [cytosol] (R-MMU-1445091)	0.611	6
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.602	6
UniProt:Q6NUN9 ZNF746	1	ZNF746 [nucleoplasm] (R-HSA-2586599)	0.591	6
UniProt:Q8IZ52-2 CHPF			0.581	5
UniProt:O95140 MFN2	5	p-S65-Ub:MFN2 [mitochondrial outer membrane] (R-HSA-9834980) K63polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-9834043) K48polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-5205668) Ub-MFN2 [mitochondrial outer membrane] (R-HSA-9835010) MFN2 [mitochondrial outer membrane] (R-HSA-992714)	0.576	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:Q9BXM7-1 PINK1			0.544	2
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.527	2
UniProt:Q8IXI2 RHOT1	2	PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139) RHOT1 [mitochondrial outer membrane] (R-HSA-3006728)	0.524	3
UniProt:O14818-1 PSMA7			0.524	5
UniProt:Q16342 PDCD2			0.508	5
UniProt:Q99IB8-PRO_0000045592			0.508	3
UniProt:Q9Z2Q6 SEPT5			0.508	2
UniProt:O35964	1	Sh3gl1 [cytosol] (R-RNO-8867732)	0.462	2
UniProt:O35179 Sh3gl2	5	Sh3gl2 [Golgi membrane] (R-RNO-351189) Sh3gl2 [clathrin-coated endocytic vesicle membrane] (R-RNO-2130629) Sh3gl2 [cytosol] (R-RNO-182958) Endophilin [plasma membrane] (R-RNO-182026) Sh3gl2 [plasma membrane] (R-RNO-177495)	0.462	2
UniProt:Q99963-3 SH3GL3			0.462	2

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