Reactome | PARK2 autoubiquitinates

PARK2 autoubiquitinates

Stable Identifier

R-HSA-5689111

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ubiquitin conjugates linked via lysine-48 (K48) target substrates to the proteasome, whereas those linked via any of the six other ubiquitin lysines can alter the function of the modified protein without leading to degradation. Parkin (PARK2) was found to autoubiquitinate itself predominantly via K6, K27, K29 and K63-linked ubiquitination, rather than via K48 (Durcan et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20940148	The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability Durcan, TM, Fon, EA, Williams, AJ, Djarmati, A, Fantaneanu, T, Kontogiannea, M, Fallon, L, Paulson, HL, Thorarinsdottir, T	Hum. Mol. Genet.	2011