Reactome | NDUFAF4 [mitochondrial inner membrane]

NDUFAF4 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5689124

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4, NDUF4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9P032 NDUFAF4

Gene Names

NDUFAF4, C6orf66, HRPAP20, HSPC125, My013

Chain

initiator methionine:1, chain:2-175

Reference Genes

BioGPS Gene:29078 NDUFAF4

COSMIC (genes):NDUFAF4 NDUFAF4

CTD Gene:29078 NDUFAF4

dbSNP Gene:29078 NDUFAF4

ENSEMBL:ENSG00000123545 NDUFAF4

ENSEMBL:ENSG00000123545.6 NDUFAF4

HGNC:21034 NDUFAF4

KEGG Gene (Homo sapiens):29078 NDUFAF4

Monarch:29078 NDUFAF4

NCBI Gene:29078 NDUFAF4

OMIM:611776 NDUFAF4

UCSC:Q9P032 NDUFAF4

Reference Transcript

RefSeq:NM_014165.3 NDUFAF4

Other Identifiers

11720191_s_at

11720192_at

11720193_x_at

219006_PM_at

219006_at

227559_PM_at

227559_at

29078

2965675

2965676

2965677

2965678

2965681

2965686

2965687

43987_at

53035_at

53605_at

8128322

A_24_P171983

A_24_P46659

GE58562

GO:0005515

GO:0005516

GO:0005739

GO:0005743

GO:0005829

GO:0007005

GO:0008284

GO:0010257

GO:0012501

GO:0016020

GO:0031966

GO:0032981

GO:0043066

GO:0043226

GO:0051607

GO:0065003

GO:0098542

HMNXSV003038731

Hs.5232.1.A1_3p_at

ILMN_1659524

ILMN_2205350

PH_hs_0026725

TC06001956.hg

g7661785_3p_at

g7661785_3p_x_at

Participates

as an output of

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)

as a component of

Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)

as an input of

IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)

Inferred To

NDUFAF4 [mitochondrial inner membrane] (Bos taurus)

NDUFAF4 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFAF4 [mitochondrial inner membrane] (Canis familiaris)

NDUFAF4 [mitochondrial inner membrane] (Danio rerio)

NDUFAF4 [mitochondrial inner membrane] (Drosophila melanogaster)

NDUFAF4 [mitochondrial inner membrane] (Gallus gallus)

NDUFAF4 [mitochondrial inner membrane] (Sus scrofa)

Ndufaf4 [mitochondrial inner membrane] (Mus musculus)

Ndufaf4 [mitochondrial inner membrane] (Rattus norvegicus)

ndufaf4 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_054884.1

OpenTargets

ENSG00000123545

GeneCards

Q9P032

HPA

ENSG00000123545-NDUFAF4

Ensembl

ENST00000316149, ENSP00000358272, ENSG00000123545

PRO

Q9P032

Pharos - Targets

Q9P032

Orphanet

17664

HMDB Protein

HMDBP08888

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BU61 NDUFAF3	1	NDUFAF3 [mitochondrial inner membrane] (R-HSA-5689126)	0.806	10
UniProt:Q9BU61-2 NDUFAF3			0.718	8
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.643	6
UniProt:Q9P0J0 NDUFA13	1	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936)	0.643	4
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.527	3
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.527	2
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	8
UniProt:Q9H7D7 WDR26			0.508	2