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NDUFAF4 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5689124
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4, NDUF4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P032 NDUFAF4
Gene Names
NDUFAF4, C6orf66, HRPAP20, HSPC125, My013
Chain
initiator methionine:1, chain:2-175
Reference Genes
BioGPS Gene:29078 NDUFAF4
COSMIC (genes):NDUFAF4 NDUFAF4
CTD Gene:29078 NDUFAF4
dbSNP Gene:29078 NDUFAF4
ENSEMBL:ENSG00000123545 NDUFAF4
ENSEMBL:ENSG00000123545.6 NDUFAF4
HGNC:21034 NDUFAF4
KEGG Gene (Homo sapiens):29078 NDUFAF4
Monarch:29078 NDUFAF4
NCBI Gene:29078 NDUFAF4
OMIM:611776 NDUFAF4
UCSC:Q9P032 NDUFAF4
Reference Transcript
RefSeq:NM_014165.3 NDUFAF4
Other Identifiers
11720191_s_at
11720192_at
11720193_x_at
219006_PM_at
219006_at
227559_PM_at
227559_at
29078
2965675
2965676
2965677
2965678
2965681
2965686
2965687
43987_at
53035_at
53605_at
8128322
A_24_P171983
A_24_P46659
GE58562
GO:0005515
GO:0005516
GO:0005739
GO:0005743
GO:0005829
GO:0007005
GO:0008284
GO:0010257
GO:0012501
GO:0016020
GO:0031966
GO:0032981
GO:0043066
GO:0043226
GO:0051607
GO:0065003
GO:0098542
HMNXSV003038731
Hs.5232.1.A1_3p_at
ILMN_1659524
ILMN_2205350
PH_hs_0026725
TC06001956.hg
g7661785_3p_at
g7661785_3p_x_at
Participates
as an output of
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
as a component of
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
as an input of
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
Inferred To
NDUFAF4 [mitochondrial inner membrane]
(Bos taurus)
NDUFAF4 [mitochondrial inner membrane]
(Caenorhabditis elegans)
NDUFAF4 [mitochondrial inner membrane]
(Canis familiaris)
NDUFAF4 [mitochondrial inner membrane]
(Danio rerio)
NDUFAF4 [mitochondrial inner membrane]
(Drosophila melanogaster)
NDUFAF4 [mitochondrial inner membrane]
(Gallus gallus)
NDUFAF4 [mitochondrial inner membrane]
(Sus scrofa)
Ndufaf4 [mitochondrial inner membrane]
(Mus musculus)
Ndufaf4 [mitochondrial inner membrane]
(Rattus norvegicus)
ndufaf4 [mitochondrial inner membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_054884.1
OpenTargets
ENSG00000123545
GeneCards
Q9P032
HPA
ENSG00000123545-NDUFAF4
Ensembl
ENST00000316149
,
ENSP00000358272
,
ENSG00000123545
PRO
Q9P032
Pharos - Targets
Q9P032
Orphanet
17664
HMDB Protein
HMDBP08888
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BU61 NDUFAF3
1
NDUFAF3 [mitochondrial inner membrane]
(R-HSA-5689126)
0.806
10
UniProt:Q9BU61-2 NDUFAF3
0.718
8
UniProt:O75251 NDUFS7
1
NDUFS7 [mitochondrial matrix]
(R-HSA-6788521)
0.643
6
UniProt:Q9P0J0 NDUFA13
1
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
0.643
4
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.527
3
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.527
2
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.527
8
UniProt:Q9H7D7 WDR26
0.508
2
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